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Fast Reductive Ligation of S‐Nitrosothiols
Journal article   Peer reviewed

Fast Reductive Ligation of S‐Nitrosothiols

Hua Wang and Ming Xian
Angewandte Chemie (International ed.), Vol.47(35), pp.6598-6601
08/18/2008
Handle:
https://hdl.handle.net/2376/109908
PMID: 18642267

Abstract

S‐nitrosothiols reductive ligation nitrogen oxides nitrenes
“Nitroso” knows: A process has been developed which converts unstable S‐nitrosothiols into stable sulfenamide analogues (see scheme). Reductive ligation proceeds rapidly in mixed organic solvent/water systems to give high yields. By applying this reaction, an efficient strategy for detecting S‐nitrosylation in proteins and other biological systems is envisioned.

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