Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila

Jason R Gerstner; William M Vanderheyden; Paul J Shaw; Charles F Landry; Jerry C P Yin

doi:10.1371/journal.pone.0015890

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Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila

Journal article

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Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila

Jason R Gerstner, William M Vanderheyden, Paul J Shaw, Charles F Landry and Jerry C P Yin

PloS one, Vol.6(1), pp.e15890-e15890

01/27/2011

DOI: https://doi.org/10.1371/journal.pone.0015890

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https://hdl.handle.net/2376/108832

PMCID: PMC3029266

PMID: 21298037

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Abstract

Drosophila Proteins - physiology

Nerve Tissue Proteins - chemistry

Nerve Tissue Proteins - physiology

Animals

Drosophila melanogaster - physiology

Sleep

Animals, Genetically Modified

Memory, Long-Term

Fatty Acid-Binding Protein 7

Fatty Acid-Binding Proteins - chemistry

Mice

Fatty Acid-Binding Proteins - physiology

Sleep is thought to be important for memory consolidation, since sleep deprivation has been shown to interfere with memory processing. However, the effects of augmenting sleep on memory formation are not well known, and testing the role of sleep in memory enhancement has been limited to pharmacological and behavioral approaches. Here we test the effect of overexpressing the brain-type fatty acid binding protein (Fabp7) on sleep and long-term memory (LTM) formation in Drosophila melanogaster. Transgenic flies carrying the murine Fabp7 or the Drosophila homologue dFabp had reduced baseline sleep but normal LTM, while Fabp induction produced increases in both net sleep and LTM. We also define a post-training consolidation "window" that is sufficient for the observed Fabp-mediated memory enhancement. Since Fabp overexpression increases consolidated daytime sleep bouts, these data support a role for longer naps in improving memory and provide a novel role for lipid-binding proteins in regulating memory consolidation concurrently with changes in behavioral state.

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Title: Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila
Creators: Jason R Gerstner - Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. gerstner@upenn.edu
William M Vanderheyden
Paul J Shaw
Charles F Landry
Jerry C P Yin
Publication Details: PloS one, Vol.6(1), pp.e15890-e15890
Academic Unit: Biomedical Sciences, Department of
Publisher: United States
Grant note: MH60774 / NIMH NIH HHS T32 GM007507 / NIGMS NIH HHS R01 MH060774 / NIMH NIH HHS GM07507 / NIGMS NIH HHS R01 NS063245 / NINDS NIH HHS
Identifiers: 99900547383401842
Language: English
Resource Type: Journal article