Journal article
Feline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms
The Veterinary clinics of North America. Small animal practice, Vol.43(5), pp.1039-1054
09/2013
Handle:
https://hdl.handle.net/2376/112667
PMCID: PMC3811070
PMID: 23890237
Abstract
Although it is widely appreciated that cats respond differently to certain drugs compared with other companion animal species, the causes of these differences are poorly understood. This article evaluates published evidence for altered drug effects in cats, focusing on pharmacokinetic differences between cats, dogs, and humans, and the molecular mechanisms underlying these differences. More work is needed to better understand drug metabolism and disposition differences in cats, thereby enabling more rational prescribing of existing medications, and the development of safer drugs for this species.
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Details
- Title
- Feline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms
- Creators
- Michael H Court - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA. Michael.Court@vetmed.wsu.edu
- Publication Details
- The Veterinary clinics of North America. Small animal practice, Vol.43(5), pp.1039-1054
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- United States
- Grant note
- R01 GM102130 / NIGMS NIH HHS R01 GM061834 / NIGMS NIH HHS
- Identifiers
- 99900547580801842
- Language
- English
- Resource Type
- Journal article