Journal article
Femtosecond time-resolved guanine oxidation in acridine modified alanyl peptide nucleic acids
Bioorganic & medicinal chemistry letters, Vol.14(7), pp.1629-1632
2004
Handle:
https://hdl.handle.net/2376/118449
PMID: 15026038
Abstract
Alanyl peptide nucleic acids have been designed to generate linear and rigid pairing complexes. Femtosecond time resolved electron transfer dynamics studies of alanyl–PNA double strands where both strands contain an intercalated 9-amino-6-chloro-2-methoxy-acridine in its protonated state reveal a strong similarity to nearest neighbor interstrand/intrastrand guanine oxidation in the corresponding B-DNA fragment. This observation implies that the combined influence of electronic couplings and energetic parameters, driving force and reorganization energy, on electron transfer dynamics is similar in both structures. With respect to the alanyl–PNA structure, this result is consistent with the notion of stacking distances in the nucleobase staple similar to the one in B-DNA and thus provides additional structural evidence for nucleobase stacking in alanyl–PNA double strands.
Femtosecond time resolved electron transfer dynamics of alanyl–PNA double strands where both strands contain an intercalated 9-amino-6-chloro-2-methoxy-acridine in its protonated state are investigated.
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Details
- Title
- Femtosecond time-resolved guanine oxidation in acridine modified alanyl peptide nucleic acids
- Creators
- D Weicherding - Institut für Organische und Biomolekulare Chemie, Universität Göttingen, Tammannstr. 2, D-37077 Göttingen, GermanyW.B Davis - Institut für Physikalische und Theoretische Chemie, TU-München, Lichtenbergstr. 4, D-85748 Garching, GermanyS Hess - Institut für Physikalische und Theoretische Chemie, TU-München, Lichtenbergstr. 4, D-85748 Garching, GermanyT von Feilitzsch - Institut für Physikalische und Theoretische Chemie, TU-München, Lichtenbergstr. 4, D-85748 Garching, GermanyM.E Michel-Beyerle - Institut für Physikalische und Theoretische Chemie, TU-München, Lichtenbergstr. 4, D-85748 Garching, GermanyU Diederichsen - Institut für Organische und Biomolekulare Chemie, Universität Göttingen, Tammannstr. 2, D-37077 Göttingen, Germany
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.14(7), pp.1629-1632
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900548451801842
- Language
- English
- Resource Type
- Journal article