Journal article
Fibroblast Growth Factor Receptor Two (FGFR2) Regulates Uterine Epithelial Integrity and Fertility in Mice
Biology of reproduction, Vol.90(1), pp.7-7
01/01/2014
Handle:
https://hdl.handle.net/2376/116043
PMID: 24227756
Abstract
Abstract Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate luminal epithelial (LE) cell proliferation in the adult mouse uterus. This study tested the hypothesis that FGFR2 has a biological role in postnatal development and function of the uterus by conditionally deletingFgfr2 after birth using progesterone receptor (Pgr)-Cre mice. AdultFgfr2 mutant female mice were initially subfertile and became infertile with increasing parity. No defects in uterine gland development were observed in conditionalFgfr2 mutant mice. In the adult,Fgfr2 mutant mice possessed a histologically normal reproductive tract with the exception of the uterus. The LE of theFgfr2 mutant uterus was stratified, but no obvious histological differences were observed in the glandular epithelium, stroma, or myometrium. Within the stratified LE, cuboidal basal cells were present and positive for basal cell markers (KRT14 and TRP63). Nulliparous bredFgfr2 mutants contained normal numbers of blastocysts on Day 3.5 postmating, but the number of embryo implantation sites was substantially reduced on Day 5.5 postmating. These results support the idea that loss of FGFR2 in the uterus after birth alters its development, resulting in LE stratification and peri-implantation pregnancy loss.
Metrics
10 Record Views
Details
- Title
- Fibroblast Growth Factor Receptor Two (FGFR2) Regulates Uterine Epithelial Integrity and Fertility in Mice
- Creators
- Justyna Filant - Center for Reproductive Biology, Department of Animal Sciences, Washington State University, Pullman, WashingtonFranco J DeMayo - Molecular and Cell Biology, Baylor College of Medicine, Houston, TexasJames K Pru - Center for Reproductive Biology, Department of Animal Sciences, Washington State University, Pullman, WashingtonJohn P Lydon - Molecular and Cell Biology, Baylor College of Medicine, Houston, TexasThomas E Spencer - Center for Reproductive Biology, Department of Animal Sciences, Washington State University, Pullman, Washington
- Publication Details
- Biology of reproduction, Vol.90(1), pp.7-7
- Academic Unit
- Animal Sciences, Department of
- Identifiers
- 99900547588701842
- Language
- English
- Resource Type
- Journal article