Files and links (2)
CC BY V4.0, Open Access
Journal article
Fine-Tuning Pyridinic Nitrogen in Nitrogen-Doped Porous Carbon Nanostructures for Boosted Peroxidase-Like Activity an Sensitive Biosensing
RESEARCH, Vol.2020, p.8202584
2020
PMID: 33623911
Abstract
Carbon materials have been widely used as nanozymes in bioapplications, attributing to their intrinsic enzyme-like activities. Nitrogen (N)-doping has been explored as a promising way to improve the activity of carbon material-based nanozymes (CMNs). However, hindered by the intricate N dopants, the real active site of N-doped CMNs (N-CMNs) has been rarely investigated, which subsequently retards the further progress of high-performance N-CMNs. Here, a series of porous N-CMNs with well-controlled N dopants were synthesized, of which the intrinsic peroxidase (POD)like activity has a positive correlation with the pyridinic N content. Density functional theory calculations also reveal that pyridinic N boosts the intrinsic POD-like activity of N-CMNs. Pyridinic-N dopant can effectively promote the first H2O desorption process in comparison with the graphitic and pyrrolic N, which is the key endothermic reaction during the catalytic process. Then, utilizing the optimized nanozymes with high pyridinic N content (N-p-CMNs) and superior POD-like activity, a facile total antioxidant capacity (TAC) assay was developed, holding great promise in the quality assessment of medicine tablets and antioxidant food for healthcare and healthy diet.
Metrics
1 Record Views
Details
- Title
- Fine-Tuning Pyridinic Nitrogen in Nitrogen-Doped Porous Carbon Nanostructures for Boosted Peroxidase-Like Activity an Sensitive Biosensing
- Creators
- Hongye Yan - Central China Normal UniversityLinzhe Wang - China University of Petroleum, BeijingYifeng Chen - Central China Normal UniversityLei Jiao - Central China Normal UniversityYu Wu - Central China Normal UniversityWeiqing Xu - Central China Normal UniversityWenling Gu - Central China Normal UniversityWeiyu Song - China University of Petroleum, BeijingDan Du - Washington State UniversityChengzhou Zhu - Central China Normal University
- Publication Details
- RESEARCH, Vol.2020, p.8202584
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Amer Assoc Advancement Science
- Number of pages
- 11
- Grant note
- 21503273 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) B17019 / Program of Introducing Talents of Discipline to Universities of China (111 programs) CCNU 20TS013 / Fundamental Research Funds for the Central Universities
- Identifiers
- 99901227840801842
- Language
- English
- Resource Type
- Journal article