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Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research
Journal article   Open access  Peer reviewed

Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research

Frederick S vom Saal, Benson T Akingbemi, Scott M Belcher, David A Crain, David Crews, Linda C Guidice, Patricia A Hunt, Csaba Leranth, John Peterson Myers, Angel Nadal, …
Toxicological sciences, Vol.115(2), pp.612-613
06/2010
DOI: https://doi.org/10.1093/toxsci/kfq048
Handle:
https://hdl.handle.net/2376/114234
PMID: 20164146
url
https://doi.org/10.1093/toxsci/kfq048View
Published (Version of record) Open

Abstract

Guidelines as Topic Rats, Long-Evans Rats Toxicity Tests - standards Male Genitalia, Female - drug effects Maternal Exposure Endocrine Disruptors - toxicity Dose-Response Relationship, Drug Ethinyl Estradiol - toxicity Pregnancy No-Observed-Adverse-Effect Level Animals Estrogens, Non-Steroidal - toxicity Fertility - drug effects Female Research Design - standards Toxicity Tests - methods Genitalia, Female - abnormalities

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