Journal article
Fluorescent probes based on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging
Chemistry : a European journal, Vol.20(4), pp.1010-1016
01/20/2014
Handle:
https://hdl.handle.net/2376/115994
PMID: 24339269
Abstract
The design, synthesis, properties, and cell imaging applications of a series of 2-pyridyl disulfide based fluorescent probes (WSP1, WSP2, WSP3, WSP4 and WSP5) for hydrogen sulfide detection are reported. The strategy is based on the dual-nucleophilicity of hydrogen sulfide. A hydrogen sulfide mediated tandem nucleophilic substitution-cyclization reaction is used to release the fluorophores and turn on the fluorescence. The probes showed high sensitivity and selectivity for hydrogen sulfide over other reactive sulfur species, including cysteine and glutathione.
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Details
- Title
- Fluorescent probes based on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging
- Creators
- Bo Peng - Department of Chemistry, Washington State University, Pullman, WA 99164 (USA), Fax: (+1) 509-335-8867Wei ChenChunrong LiuEthan W RosserArmando PachecoYu ZhaoHector C AguilarMing Xian
- Publication Details
- Chemistry : a European journal, Vol.20(4), pp.1010-1016
- Academic Unit
- Chemistry, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- Germany
- Grant note
- R01 GM088226 / NIGMS NIH HHS R01 AI109022 / NIAID NIH HHS R01M088226 / PHS HHS
- Identifiers
- 99900547866401842
- Language
- English
- Resource Type
- Journal article