Journal article
Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension
International journal of hypertension, Vol.2012, pp.124758-12
2012
Handle:
https://hdl.handle.net/2376/109617
PMCID: PMC3389720
PMID: 22792446
Abstract
The classic renin-angiotensin system (RAS) was initially described as a hormone system designed to mediate cardiovascular and body water regulation. The discovery of a brain RAS composed of the necessary functional components (angiotensinogen, peptidases, angiotensins, and specific receptor proteins) independent of the peripheral system significantly expanded the possible physiological and pharmacological functions of this system. This paper first describes the enzymatic pathways resulting in active angiotensin ligands and their interaction with AT
1
, AT
2
, and mas receptor subtypes. Recent evidence points to important contributions by brain angiotensin III (AngIII) and aminopeptidases A (APA) and N (APN) in sustaining hypertension. Next, we discuss current approaches to the treatment of hypertension followed by novel strategies that focus on limiting the binding of AngII and AngIII to the AT
1
receptor subtype by influencing the activity of APA and APN. We conclude with thoughts concerning future treatment approaches to controlling hypertension and hypotension.
Metrics
7 Record Views
Details
- Title
- Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension
- Creators
- John W Wright - Departments of Psychology and Veterinary and Comparative Anatomy, Pharmacology, and Physiology and Programs in Neuroscience and Biotechnology, Washington State University, P.O. Box 644820, Pullman, WA 99164-4820, USAShigehiko Mizutani - Department of Medical Science of Proteases, Daiya Building Lady's Clinic, Meieki 3-15-1, Nakamura, Nagoya 450-0002, JapanJoseph W Harding - Departments of Psychology and Veterinary and Comparative Anatomy, Pharmacology, and Physiology and Programs in Neuroscience and Biotechnology, Washington State University, P.O. Box 644820, Pullman, WA 99164-4820, USA
- Publication Details
- International journal of hypertension, Vol.2012, pp.124758-12
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Hindawi Publishing Corporation
- Identifiers
- 99900547187001842
- Language
- English
- Resource Type
- Journal article