Journal article
Frequency distribution of a Cys430Ser polymorphism in peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) gene sequence in Chinese and Western pig breeds
Journal of animal breeding and genetics (1986), Vol.122(1), pp.7-11
02/2005
Handle:
https://hdl.handle.net/2376/111442
PMID: 16130483
Abstract
Identification of major genes, that genetically impact fat tissue formation is important for successful selection of lean animals with good meat quality. Because of its central role in fat cell differentiation and muscle fibre type determination, PPARGC1 is a potential candidate gene affecting fattening traits and pig meat quality. In this study, a T/A substitution at position 1378 (GenBank accession no. AY346131) in the porcine PPARGC1 gene causing a Cys430Ser amino acid substitution at position 430 was genotyped on a total of 239 animals, including 101 from seven Chinese and 138 from six Western pig breeds. Bayesian analysis revealed that the mean frequency of allele T (Cys) was 92.64 +/- 4.82% in Chinese pigs, and 45.99 +/- 4.13% in Western pigs. The 95% interval of the posterior mean frequency of allele T was 0.82-1.00 in Chinese pigs and 0.38-0.54 in Western pigs, indicating these two groups of pigs diverged at this locus during genetic evolution of the breed. Because marked differences in fat and lean tissue deposition exist between Western and Chinese pig breeds, this Cys430Ser exchange in the PPARGC1 gene deserves further evaluation to determine its phenotypic effect on fattening and carcass traits in commercial pig populations.
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Details
- Title
- Frequency distribution of a Cys430Ser polymorphism in peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) gene sequence in Chinese and Western pig breeds
- Creators
- T Kunej - Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domzale, SloveniaX L WuT M BerlicJ J MichalZ JiangP Dovc
- Publication Details
- Journal of animal breeding and genetics (1986), Vol.122(1), pp.7-11
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Germany
- Identifiers
- 99900547890201842
- Language
- English
- Resource Type
- Journal article