From AR to c-Met: androgen deprivation leads to a signaling pathway switch in prostate cancer cells

Tiancheng Liu; Desiree E Mendes; Clifford E Berkman

doi:10.3892/ijo.2013.2020

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From AR to c-Met: androgen deprivation leads to a signaling pathway switch in prostate cancer cells

Journal article

Open access

Peer reviewed

From AR to c-Met: androgen deprivation leads to a signaling pathway switch in prostate cancer cells

Tiancheng Liu, Desiree E Mendes and Clifford E Berkman

International journal of oncology, Vol.43(4), pp.1125-1130

10/2013

DOI: https://doi.org/10.3892/ijo.2013.2020

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https://hdl.handle.net/2376/113008

PMCID: PMC3829778

PMID: 23877345

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https://doi.org/10.3892/ijo.2013.2020View

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Abstract

Proto-Oncogene Proteins c-met - metabolism

Prostatic Neoplasms - pathology

Signal Transduction

Humans

Gene Expression Regulation, Neoplastic

Male

Proto-Oncogene Proteins c-met - genetics

Prostatic Neoplasms - genetics

Receptors, Androgen - genetics

Receptors, Androgen - biosynthesis

Cell Line, Tumor

RNA, Small Interfering

Androgens - metabolism

Elucidating the role of androgen deprivation in the transition from androgen-dependence to independence may enable the development of more specific therapeutic strategies against prostate cancer. Our previous in vitro model was employed to further assess the effects of continuous androgen‑deprivation on prostate cancer cells (LNCaP) with respect to both androgen receptor (AR) and c-Met expression. The results indicated that long-term androgen deprivation resulted in a signaling pathway switch from AR to c-Met in androgen-sensitive cells, which was confirmed by immunofluorescence imaging and western blot analysis. This signaling pathway switch may be predictive of a more aggressive disease state following androgen deprivation therapy.

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Title: From AR to c-Met: androgen deprivation leads to a signaling pathway switch in prostate cancer cells
Creators: Tiancheng Liu - Department of Chemistry, Washington State University, Pullman, WA 99164, USA
Desiree E Mendes
Clifford E Berkman
Publication Details: International journal of oncology, Vol.43(4), pp.1125-1130
Academic Unit: Chemistry, Department of
Publisher: Greece
Grant note: R01CA140617 / NCI NIH HHS R01 CA140617 / NCI NIH HHS T32 GM008336 / NIGMS NIH HHS
Identifiers: 99900547746101842
Language: English
Resource Type: Journal article