Journal article
Functional and Phenotypic Characterization of WC1 + γ/δ T Cells Isolated from Babesia bovis-Stimulated T Cell Lines
Cellular immunology, Vol.153(1), pp.9-27
1994
Handle:
https://hdl.handle.net/2376/100379
PMID: 7507005
Abstract
Functional studies with WC1
+ γ/δ T cell lines were performed to clarify the role of this subpopulation of γ/δ T cells in the
in vitro immune response to
Babesia bovis. As CD4
+ T cells decreased and γ/δ T cells increased in
B. bovis -stimulated T cell lines, antigen-specific proliferation declined to background levels. One irradiated γ/δ T cell line inhibited proliferation of autologous Th1 cells, although unirradiated γ/δ T cells either synergized with or had no effect on Th cell proliferation. γ/δ T cells were not cytolytic for bovine α/β T cells, but expressed natural killer (NK)-like cytotoxicity when assayed on xenogeneic NK-sensitive target cells. The γ/δ T cells were IL-2 dependent and expressed IFN-γ and TNF-α, but not TNF-β. IL-2. or IL-4 mRNA. Together, these results raise the possibility that WC1
+ γ/δ T cells respond
in vitro to autoantigens present on CD4
+ T cells or to cytokines secreted by activated CD4
+ T cells, resulting in modulation of the CD4
+ T cell response and outgrowth of the γ/δ T cells in parasite-stimulated lines.
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Details
- Title
- Functional and Phenotypic Characterization of WC1 + γ/δ T Cells Isolated from Babesia bovis-Stimulated T Cell Lines
- Creators
- Wendy C BrownWilliam C DavisSang H ChoiDirk A.E DobbelaereGary A Splitter
- Publication Details
- Cellular immunology, Vol.153(1), pp.9-27
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546616901842
- Language
- English
- Resource Type
- Journal article