Journal article
Gas Phase Chiral Separations By Ion Mobility Spectrometry
Analytical chemistry (Washington), Vol.78(24), pp.8200-8206
12/15/2006
Handle:
https://hdl.handle.net/2376/115227
PMCID: PMC3633475
PMID: 17165808
Abstract
This manuscript introduces the concept of Chiral Ion Mobility Spectrometry (CIMS) and presents examples demonstrating the gas phase separation of enantiomers of a wide range of racemates including pharmaceuticals, amino acids and carbohydrates. CIMS is similar to traditional ion mobility spectrometry (IMS), where gas phase ions, when subjected to a potential gradient are separated at atmospheric pressure due to differences in their shapes and sizes. In addition to size and shape, CIMS separates ions based on their stereospecific interaction with a chiral gas. In order to achieve chiral discrimination by CIMS, an asymmetric environment was provided by doping the drift gas with a volatile chiral reagent. In this study S-(+)-2-butanol was used as a chiral modifier to demonstrate enantiomeric separations of atenolol, serine, methionine, threonine, methyl-α-glucopyranoside, glucose, penicillamine, valinol, phenylalanine, and tryptophan from their respective racemic mixtures.
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Details
- Title
- Gas Phase Chiral Separations By Ion Mobility Spectrometry
- Creators
- Prabha Dwivedi - Department of Chemistry, Washington State University, Pullman, WA 99164Ching Wu - Excellims Corporation, Acton, MA 01720Herbert H Hill - Department of Chemistry, Washington State University, Pullman, WA 99164
- Publication Details
- Analytical chemistry (Washington), Vol.78(24), pp.8200-8206
- Academic Unit
- Chemistry, Department of
- Identifiers
- 99900548489601842
- Language
- English
- Resource Type
- Journal article