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CC BY V4.0, Open Access
Journal article
Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: Environmental epigenetics and evolutionary biology
BMC genomics, Vol.15(1), pp.377-377
05/16/2014
Handle:
https://hdl.handle.net/2376/106189
PMCID: PMC4073506
PMID: 24885959
Abstract
Background: Mate preference behavior is an essential first step in sexual selection and is a critical determinant in evolutionary biology. Previously an environmental compound (the fungicide vinclozolin) was found to promote the epigenetic transgenerational inheritance of an altered sperm epigenome and modified mate preference characteristics for three generations after exposure of a gestating female. Results: The current study investigated gene networks involved in various regions of the brain that correlated with the altered mate preference behavior in the male and female. Statistically significant correlations of gene clusters and modules were identified to associate with specific mate preference behaviors. This novel systems biology approach identified gene networks (bionetworks) involved in sex-specific mate preference behavior. Observations demonstrate the ability of environmental factors to promote the epigenetic transgenerational inheritance of this altered evolutionary biology determinant. Conclusions: Combined observations elucidate the potential molecular control of mate preference behavior and suggests environmental epigenetics can have a role in evolutionary biology.
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Details
- Title
- Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: Environmental epigenetics and evolutionary biology
- Creators
- Michael K Skinner - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236 USAMarina I Savenkova - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236 USABin Zhang - Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY 10029 USAAndrea C Gore - Pharmacology and Toxicology, Austin, TexasDavid Crews - Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712 USA
- Publication Details
- BMC genomics, Vol.15(1), pp.377-377
- Academic Unit
- Biological Sciences, School of
- Publisher
- BioMed Central; London
- Identifiers
- 99900546995401842
- Language
- English
- Resource Type
- Journal article