Journal article
Genetic analysis of microsomal epoxide hydrolase gene and its association with lung cancer risk
European journal of cancer prevention, Vol.14(3), pp.223-230
06/2005
Handle:
https://hdl.handle.net/2376/108419
PMCID: PMC3715303
PMID: 15901990
Abstract
The human microsomal epoxide hydrolase (EH) gene contains polymorphic alleles, which may be linked to increased risk for tobacco-related lung cancer. The purpose of this study is to screen new polymorphisms and determine whether these polymorphisms can be used to predict individual susceptibility to lung cancer. The PCR-single strand conformation polymorphism (SSCP) analysis was used to screen for polymorphisms in the coding region of the EH gene. Eleven polymorphisms, including previously reported polymorphisms, were identified and the prevalence of these variants was assessed in at least 50 healthy Caucasians and African Americans. Among the eleven polymorphisms, the prevalence of the amino acid-changing EH polymorphisms in codons 43, 113, and 139 was examined in 182 Caucasian incident cases with primary lung cancer, as well as in 365 frequency-matched controls to examine the role of EH polymorphisms in lung cancer risk. A significant increase in lung cancer risk was observed for predicted high EH activity genotypes (OR = 2.3, 95% CI = 1.2–4.3) as compared to low EH activity genotypes. This association was more pronounced among patients with lung adenocarcinoma (OR = 4.7, 95% CI = 1.7–13.1). These results suggest that the EH polymorphism plays an important role in lung cancer risk and is linked to tobacco smoke exposure.
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Details
- Title
- Genetic analysis of microsomal epoxide hydrolase gene and its association with lung cancer risk
- Creators
- Jong Y Park - Division of Cancer Prevention and Control, 12902 Magnolia drive, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612. USALan Chen - Division of Cancer Prevention and Control, 12902 Magnolia drive, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612. USAAbul Elahi - Division of Cancer Prevention and Control, 12902 Magnolia drive, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612. USAPhilip Lazarus - Division of Cancer Prevention and Control, 12902 Magnolia drive, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612. USAMelvyn S Tockman - Division of Cancer Prevention and Control, 12902 Magnolia drive, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612. USA
- Publication Details
- European journal of cancer prevention, Vol.14(3), pp.223-230
- Academic Unit
- Pharmaceutical Sciences, Department of
- Grant note
- R03 CA091314 || CA / National Cancer Institute : NCI
- Identifiers
- 99900546991701842
- Language
- English
- Resource Type
- Journal article