Journal article
Genetic ancestry, skin reflectance and pigmentation genotypes in association with serum vitamin D metabolite balance
Hormone molecular biology and clinical investigation, Vol.7(1), pp.279-293
10/01/2011
Handle:
https://hdl.handle.net/2376/110195
PMCID: PMC3606023
PMID: 23525585
Abstract
Lower serum vitamin D (25(OH)D) among individuals with African ancestry is primarily attributed to skin pigmentation. However, the influence of genetic polymorphisms controlling for skin melanin content has not been investigated. Therefore, we investigated differences in non-summer serum vitamin D metabolites according to self-reported race, genetic ancestry, skin reflectance and key pigmentation genes (
and
Healthy individuals reporting at least half African American or half European American heritage were frequency matched to one another on age (±2 years) and sex. One hundred and seventy-six autosomal ancestry informative markers were used to estimate genetic ancestry. Melanin index was measured by reflectance spectrometry. Serum vitamin D metabolites [25(OH)D
, 25(OH)D
and 24,25(OH)
] were determined by high performance liquid chromatography (HPLC) tandem mass spectrometry. Percent 24,25(OH)
was calculated as a percent of the parent metabolite [25(OH)D
]. Stepwise and backward selection regression models were used to identify leading covariates.
Fifty African Americans and 50 European Americans participated in the study. Compared with
111
homozygotes, individuals with the
111
and 111
genotypes had, respectively, lower levels of 25(OH)D
(23.0 and 23.8 nmol/L lower, p-dominant=0.007), and percent 24,25(OH)
(4.1% and 5.2% lower, p-dominant=0.003), controlling for tanning bed use, vitamin D/fish oil supplement intake, race/ethnicity and genetic ancestry. Results were similar with melanin index adjustment, and were not confounded by glucocorticoid, oral contraceptive, or statin use.
The
111
allele was associated with lower serum vitamin 25(OH)D
and lower percent 24,25(OH)
, independently from melanin index and West African genetic ancestry.
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Details
- Title
- Genetic ancestry, skin reflectance and pigmentation genotypes in association with serum vitamin D metabolite balance
- Creators
- Robin Taylor Wilson - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USAAlanna N Roff - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USAP. Jenny Dai - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USATracey Fortugno - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USAJonathan Douds - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USAGang Chen - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USAGary L Grove - Cyberderm, Inc. 700 Park Way, Broomall, PA, USASheila Ongeri Nikiforova - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USAJill Barnholtz-Sloan - Division of General Medical Sciences, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH, USATony Frudakis - DNAPrint Genomics, Inc., Sarasota, FL, USAVernon M Chinchilli - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USATerryl J Hartman - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USALaurence M Demers - Penn State Hershey College of Medicine, and Penn State Hershey Cancer Institute, The Pennsylvania State University, Hershey, PA, USAMark D Shriver - Department of Anthropology, The Pennsylvania State University, University Park, PA, USAVictor A Canfield - Jake Gittlen Cancer Research Foundation and Division of Experimental Pathology, The Pennsylvania State University, Hershey, PA, USAKeith C Cheng
- Publication Details
- Hormone molecular biology and clinical investigation, Vol.7(1), pp.279-293
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- Walter de Gruyter
- Identifiers
- 99900547472101842
- Language
- English
- Resource Type
- Journal article