Journal article
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study
The American journal of clinical nutrition, Vol.104(2), pp.371-379
08/2016
Handle:
https://hdl.handle.net/2376/109810
PMID: 27413137
Abstract
Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking.
We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments.
Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling.
The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions.
Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.
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- Title
- Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study
- Creators
- Karri Silventoinen - Departments of Social Research and Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan; karri.silventoinen@helsinki.fiAline Jelenkovic - Departments of Social Research and Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, SpainReijo Sund - Departments of Social Research andYoon-Mi Hur - Department of Education, Mokpo National University, Jeonnam, South KoreaYoshie Yokoyama - Department of Public Health Nursing, Osaka City University, Osaka, JapanChika Honda - Osaka University Graduate School of Medicine, Osaka University, Osaka, JapanJacob vB Hjelmborg - The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, andSören Möller - The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, andSyuichi Ooki - Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, JapanSari Aaltonen - Departments of Social Research and Public Health, University of Helsinki, Helsinki, FinlandFuling Ji - Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, ChinaFeng Ning - Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, ChinaZengchang Pang - Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, ChinaEsther Rebato - Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, SpainAndreas Busjahn - HealthTwiSt GmbH, Berlin, GermanyChristian Kandler - Department of Psychology, Bielefeld University, Bielefeld, GermanyKimberly J Saudino - Department of Psychological and Brain Sciences, Boston University, Boston, MAKerry L Jang - Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, CanadaWendy Cozen - Department of Preventive Medicine, Keck School of Medicine of USC, and USC Norris Comprehensive Cancer Center, Los Angeles, CAAmie E Hwang - Department of Preventive Medicine, Keck School of Medicine of USC, andThomas M Mack - Department of Preventive Medicine, Keck School of Medicine of USC, and USC Norris Comprehensive Cancer Center, Los Angeles, CAWenjing Gao - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaCanqing Yu - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaLiming Li - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaRobin P Corley - Institute for Behavioral Genetics, Boulder, COBrooke M Huibregtse - Institute for Behavioral Genetics, Boulder, COKaare Christensen - The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and Departments of Clinical Biochemistry and Pharmacology Clinical GeneticsAxel Skytthe - The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, andKirsten O Kyvik - Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Odense Patient data Explorative Network, andCatherine A Derom - Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium; Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, BelgiumRobert F Vlietinck - Centre of Human Genetics, University Hospitals Leuven, Leuven, BelgiumRuth Jf Loos - The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NYKauko Heikkilä - Public Health, University of Helsinki, Helsinki, FinlandJane Wardle - Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United KingdomClare H Llewellyn - Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United KingdomAbigail Fisher - Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United KingdomTom A McAdams - Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom; MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, andThalia C Eley - MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, andAlice M Gregory - Department of Psychology, Goldsmiths, University of London, London, United KingdomMingguang He - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Centre for Eye Research Australia, University of Melbourne, Melbourne, AustraliaXiaohu Ding - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaMorten Bjerregaard-Andersen - Departments of Endocrinology and Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau; Research Center for Vitamins and Vaccines, Statens Serum Institute, Copenhagen, DenmarkHenning Beck-Nielsen - Departments of Endocrinology andMorten Sodemann - Departments of Endocrinology and Infectious Diseases, Odense University Hospital, Odense, DenmarkAdam D Tarnoki - Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary; Hungarian Twin Registry, Budapest, HungaryDavid L Tarnoki - Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary; Hungarian Twin Registry, Budapest, HungaryMaria A Stazi - Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, ItalyCorrado Fagnani - Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, ItalyCristina D'Ippolito - Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, ItalyAriel Knafo-Noam - The Hebrew University of Jerusalem, Jerusalem, IsraelDavid Mankuta - Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, IsraelLior Abramson - The Hebrew University of Jerusalem, Jerusalem, IsraelS Alexandra Burt - Michigan State University, East Lansing, MIKelly L Klump - Michigan State University, East Lansing, MIJudy L Silberg - Department of Human and Molecular GeneticsLindon J Eaves - Department of Human and Molecular GeneticsHermine H Maes - Department of Human and Molecular Genetics, Massey Cancer Center, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VARobert F Krueger - Department of Psychology, University of Minnesota, Minneapolis, MNMatt McGue - Department of Psychology, University of Minnesota, Minneapolis, MNShandell Pahlen - Department of Psychology, University of Minnesota, Minneapolis, MNMargaret Gatz - Department of Psychology, University of Southern California, Los Angeles, CA; Departments of Medical Epidemiology and Biostatistics andDavid A Butler - Institute of Medicine, National Academy of Sciences Washington, DCMeike Bartels - Department of Biological Psychology, VU University Amsterdam, Amsterdam, NetherlandsToos Cem van Beijsterveldt - Department of Biological Psychology, VU University Amsterdam, Amsterdam, NetherlandsJeffrey M Craig - Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, AustraliaRichard Saffery - Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, AustraliaDuarte L Freitas - Department of Physical Education and Sport, University of Madeira, Funchal, PortugalJosé Antonio Maia - Centre of Research, Education, Innovation and Intervention in Sport, Faculty of Sport, Porto, University of Porto, PortugalLise Dubois - School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, CanadaMichel Boivin - École de psychologie, Université Laval, Québec, Canada; Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Russian FederationMara Brendgen - Département de psychologie, Université du Québec à Montréal, Montréal, Québec, CanadaGinette Dionne - École de psychologie, Université Laval, Québec, CanadaFrank Vitaro - École de psychoéducation, Université de Montréal, Montréal, Québec, CanadaNicholas G Martin - Genetic Epidemiology Department andSarah E Medland - Genetic Epidemiology Department andGrant W Montgomery - Molecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, AustraliaYoungsook Chong - Department of Psychology, Pusan National University, Busan, South KoreaGary E Swan - Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CARuth Krasnow - Center for Health Sciences, SRI International, Menlo Park, CAPatrik Ke Magnusson - Departments of Medical Epidemiology and Biostatistics andNancy L Pedersen - Departments of Medical Epidemiology and Biostatistics andPer Tynelius - Public Health Sciences, Karolinska Institutet, Stockholm, SwedenPaul Lichtenstein - Departments of Medical Epidemiology and Biostatistics andClaire Ma Haworth - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United KingdomRobert Plomin - MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, andGombojav Bayasgalan - Healthy Twin Association of Mongolia, Ulaanbaatar, MongoliaDanshiitsoodol Narandalai - Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanK Paige Harden - Department of Psychology, University of Texas at Austin, Austin, TXElliot M Tucker-Drob - Department of Psychology, University of Texas at Austin, Austin, TXSevgi Y Öncel - Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, TurkeyFazil Aliev - Department of Human and Molecular Genetics, Departments of Psychiatry and PsychologyTimothy Spector - Department of Twin Research and Genetic Epidemiology, King's College, London, United KingdomMassimo Mangino - Department of Twin Research and Genetic Epidemiology, King's College, London, United KingdomGenevieve Lachance - Department of Twin Research and Genetic Epidemiology, King's College, London, United KingdomLaura A Baker - Department of Psychology, University of Southern California, Los Angeles, CACatherine Tuvblad - Department of Psychology, University of Southern California, Los Angeles, CA; Örebro University, School of Law, Psychology and Social Work, Örebro, SwedenGlen E Duncan - College of Medicine, Washington State University - Health Sciences Spokane, Spokane, WADedra Buchwald - Washington State Twin Registry, Washington State University, Seattle, WAGonneke Willemsen - Department of Biological Psychology, VU University Amsterdam, Amsterdam, NetherlandsFinn Rasmussen - Public Health Sciences, Karolinska Institutet, Stockholm, SwedenJack H Goldberg - Department of Epidemiology, School of Public Health, University of Washington, Seattle, WAThorkild Ia Sørensen - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Novo Nordisk Foundation Center for Basic Metabolic Research (Section on Metabolic Genetics) and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen,Denmark; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Copenhagen, The Capital Region, DenmarkDorret I Boomsma - Department of Biological Psychology, VU University Amsterdam, Amsterdam, NetherlandsJaakko Kaprio - Public Health, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland; and Institute for Molecular Medicine FIMM, Helsinki, Finland
- Publication Details
- The American journal of clinical nutrition, Vol.104(2), pp.371-379
- Academic Unit
- Community Health; Nutrition and Exercise Physiology, Department of
- Publisher
- United States
- Grant note
- P60 DA011015 / NIDA NIH HHS T32 DA017637 / NIDA NIH HHS R21 AG039572 / NIA NIH HHS G19/2 / Medical Research Council R01 MH062375 / NIMH NIH HHS R01 HD068435 / NICHD NIH HHS
- Identifiers
- 99900547117801842
- Language
- English
- Resource Type
- Journal article