Journal article
Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts
Scientific reports, Vol.6(1), pp.1-13
2016
Handle:
https://hdl.handle.net/2376/107990
PMCID: PMC4917845
PMID: 27333805
Abstract
Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1–19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
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Details
- Title
- Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts
- Creators
- Aline Jelenkovic - , HelsinkiReijo Sund - , HelsinkiYoon-Mi Hur - , JeonnamYoshie Yokoyama - , OsakaJacob v. B Hjelmborg - ,Sören Möller - ,Chika Honda - , OsakaPatrik K. E Magnusson - , StockholmNancy L Pedersen - , StockholmSyuichi Ooki - , Kahoku, IshikawaSari Aaltonen - , HelsinkiMaria A Stazi - , RomeCorrado Fagnani - , RomeCristina D’Ippolito - , RomeDuarte L Freitas - , FunchalJosé Antonio Maia - ,Fuling Ji - , QingdaoFeng Ning - , QingdaoZengchang Pang - , QingdaoEsther Rebato - , LeioaAndreas Busjahn - , BerlinChristian Kandler - , BielefeldKimberly J Saudino - , Boston, MAKerry L Jang - , Vancouver, BCWendy Cozen - , Los Angeles, CaliforniaAmie E Hwang - , Los Angeles, CaliforniaThomas M Mack - , Los Angeles, CaliforniaWenjing Gao - , BeijingCanqing Yu - , BeijingLiming Li - , BeijingRobin P Corley - , Boulder, ColoradoBrooke M Huibregtse - , Boulder, ColoradoCatherine A Derom - , LeuvenRobert F Vlietinck - , LeuvenRuth J. F Loos - , New York, NYKauko Heikkilä - , HelsinkiJane Wardle - , LondonClare H Llewellyn - , LondonAbigail Fisher - , LondonTom A McAdams - , LondonThalia C Eley - , LondonAlice M Gregory - , LondonMingguang He - , GuangzhouXiaohu Ding - , GuangzhouMorten Bjerregaard-Andersen - , BissauHenning Beck-Nielsen - , OdenseMorten Sodemann - , OdenseAdam D Tarnoki - , BudapestDavid L Tarnoki - , BudapestAriel Knafo-Noam - , JerusalemDavid Mankuta - , JerusalemLior Abramson - , JerusalemS. Alexandra Burt - , East Lansing, MichiganKelly L Klump - , East Lansing, MichiganJudy L Silberg - , Richmond, VirginiaLindon J Eaves - , Richmond, VirginiaHermine H Maes - , Richmond, VirginiaRobert F Krueger - , Minneapolis, MNMatt McGue - , Minneapolis, MNShandell Pahlen - , Minneapolis, MNMargaret Gatz - , StockholmDavid A Butler - , DCMeike Bartels - , AmsterdamToos C. E. M van Beijsterveldt - , AmsterdamJeffrey M Craig - , Parkville, VictoriaRichard Saffery - , Parkville, VictoriaLise Dubois - , Ottawa, OntarioMichel Boivin - , QuébecMara Brendgen - , Montréal, QuébecGinette Dionne - , QuébecFrank Vitaro - , Montréal, QuébecNicholas G Martin - , BrisbaneSarah E Medland - , BrisbaneGrant W Montgomery - , BrisbaneGary E Swan - , Stanford, CARuth Krasnow - , Menlo Park, CAPer Tynelius - , StockholmPaul Lichtenstein - , StockholmClaire M. A Haworth - , BristolRobert Plomin - , LondonGombojav Bayasgalan - , UlaanbaatarDanshiitsoodol Narandalai - , UlaanbaatarK. Paige Harden - , Austin, TXElliot M Tucker-Drob - , Austin, TXTimothy Spector - , LondonMassimo Mangino - , LondonGenevieve Lachance - , LondonLaura A Baker - , Los Angeles, CACatherine Tuvblad - , Los Angeles, CAGlen E Duncan - , Spokane, WADedra Buchwald - , Seattle, WAGonneke Willemsen - , AmsterdamAxel Skytthe - ,Kirsten O Kyvik - , OdenseKaare Christensen - ,Sevgi Y Öncel - , KırıkkaleFazil Aliev - , RichmondFinn Rasmussen - , StockholmJack H Goldberg - , Seattle, WAThorkild I. A Sørensen - , CopenhagenDorret I Boomsma - , AmsterdamJaakko Kaprio - , HelsinkiKarri Silventoinen - , Helsinki
- Publication Details
- Scientific reports, Vol.6(1), pp.1-13
- Academic Unit
- Community Health; Nutrition and Exercise Physiology, Department of
- Publisher
- Nature Publishing Group
- Identifiers
- 99900547007601842
- Language
- English
- Resource Type
- Journal article