Journal article
Genetic mouse models to investigate cell cycle regulation
Transgenic research, Vol.18(4), pp.491-498
06/01/2009
Handle:
https://hdl.handle.net/2376/117019
PMID: 19418238
Abstract
Early studies on cell cycle regulation were based on experiments in model systems (Yeast, Xenopus, Starfish, Drosophila) and have shaped the way we understand many events that control the cell cycle. Although these model systems are of great value, the last decade was highlighted by studies done in human cells and using in vivo mouse models. Mouse models are irreplaceable tools for understanding the genetics, development, and survival strategies of mammals. New developments in generating targeting vectors and mutant mice have improved our approaches to study cell cycle regulation and cancer. Here we summarize the most recent advances of mouse model approaches in dissecting the mechanisms of cell cycle regulation and the relevance to human disease.
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Details
- Title
- Genetic mouse models to investigate cell cycle regulation
- Creators
- Weimin Li - University of Wisconsin-MadisonShuhei Kotoshiba - AStar Institute of Molecular and Cell Biology (IMCB)Philipp Kaldis - AStar Institute of Molecular and Cell Biology (IMCB)
- Publication Details
- Transgenic research, Vol.18(4), pp.491-498
- Academic Unit
- Biomedical Sciences, Department of
- Identifiers
- 99900548382501842
- Language
- English
- Resource Type
- Journal article