Journal article
Genome assembly anchored QTL map of bovine chromosome 14
International journal of biological sciences, Vol.4(6), pp.406-414
2008
Handle:
https://hdl.handle.net/2376/107148
PMID: 19043607
Abstract
Bovine chromosome 14 (BTA14) has been widely explored for quantitative trait loci (QTL) and genes related to economically important traits in both dairy and beef cattle. We reviewed more than 40 investigations and anchored 126 QTL to the current genome assembly (Btau 4_0). Using this anchored QTL map, we observed that, in dairy cattle, the region spanning 0 - 10 Mb on BTA14 has the highest density QTL map with a total of 56 QTL, mainly for milk production traits. It is very likely that both somatic cell score (SCS) and clinical mastitis share some common QTL in two regions: 61.48 Mb - 73.84 Mb and 7.86 Mb - 39.55 Mb, respectively. As well, both ovulation rate and twinning rate might share a common QTL region from 34.16 Mb to 65.38 Mb. However, there are no common QTL locations in three pregnancy related phenotypes: non-return rate, pregnancy rate and daughter pregnancy rate. In beef cattle, the majority of QTL are located in a broad region of 15 Mb - 45 Mb on the chromosome. Functional genes, such as CRH, CYP11B1, DGAT1, FABP4 and TG, as potential candidates for some of these QTL, were also reviewed. Therefore, our review provides a standardized QTL map anchored within the current genome assembly, which would enhance the process of selecting positional and physiological candidate genes for many important traits in cattle.
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Details
- Title
- Genome assembly anchored QTL map of bovine chromosome 14
- Creators
- Tito A Wibowo - Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USACharles T GaskinsRuth C NewberryGary H ThorgaardJennifer J MichalZhihua Jiang
- Publication Details
- International journal of biological sciences, Vol.4(6), pp.406-414
- Academic Unit
- Animal Sciences, Department of; Biological Sciences, School of
- Publisher
- Australia
- Identifiers
- 99900547357301842
- Language
- English
- Resource Type
- Journal article