Journal article
Genomic evidence for the Pleistocene and recent population history of Native Americans
Science (American Association for the Advancement of Science), Vol.349(6250), pp.aab3884-aab3884
08/21/2015
Handle:
https://hdl.handle.net/2376/112967
PMCID: PMC4733658
PMID: 26198033
Abstract
How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we find that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (KYA), and after no more than 8,000-year isolation period in Beringia. Following their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 KYA, one that is now dispersed across North and South America and the other is restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative ‘Paleoamerican’ relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.
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Details
- Title
- Genomic evidence for the Pleistocene and recent population history of Native Americans
- Creators
- Maanasa Raghavan - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkMatthias Steinrücken - Computer Science Division, University of California, Berkeley, CA 94720, USAKelley Harris - Department of Mathematics, University of California, Berkeley, CA 94720, USAStephan Schiffels - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UKSimon Rasmussen - Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, 2800 Kongens Lyngby, DenmarkMichael DeGiorgio - Departments of Biology and Statistics, Pennsylvania State University, 502 Wartik Laboratory, University Park, PA 16802, USAAnders Albrechtsen - The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, DenmarkCristina Valdiosera - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkMaría C Ávila-Arcos - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkAnna-Sapfo Malaspinas - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkAnders Eriksson - Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UKIda Moltke - The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, DenmarkMait Metspalu - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, EstoniaJulian R Homburger - Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USAJeff Wall - Institute for Human Genetics, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USAOmar E Cornejo - School of Biological Sciences, Washington State University, PO Box 644236, Heald 429, Pullman, Washington 99164, USAJ. Víctor Moreno-Mayar - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkThorfinn S Korneliussen - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkTracey Pierre - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkMorten Rasmussen - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkPaula F Campos - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkPeter de Barros Damgaard - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkMorten E Allentoft - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkJohn Lindo - Department of Anthropology, University of Illinois at Urbana-Champaign, 607 S. Mathews Ave, Urbana, IL 61801, USAEne Metspalu - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, EstoniaRicardo Rodríguez-Varela - Centro Mixto, Universidad Complutense de Madrid–Instituto de Salud Carlos III de Evolución y Comportamiento Humano, Madrid, SpainJosefina Mansilla - Instituto Nacional de Antropología e Historia, Moneda 13, Centro, Cuauhtémoc, 06060 Mexico Mexico City, MexicoCeleste Henrickson - University of Utah, Department of Anthropology, 270 S 1400 E, Salt Lake City, Utah 84112, USAAndaine Seguin-Orlando - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkHelena Malmström - Department of Evolutionary Biology and Science for Life Laboratory, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, SwedenThomas Stafford - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkSuyash S Shringarpure - Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USAAndrés Moreno-Estrada - Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USAMonika Karmin - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, EstoniaKristiina Tambets - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, EstoniaAnders Bergström - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UKYali Xue - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UKVera Warmuth - UCL Genetics Institute, Gower Street, London WC1E 6BT, UKAndrew D Friend - Department of Geography, University of Cambridge, Downing Place, Cambridge CB2 3EN, UKJoy Singarayer - Centre for Past Climate Change and Department of Meteorology, University of Reading, Earley Gate, PO Box 243, Reading, UKPaul Valdes - School of Geographical Sciences, University Road, Clifton, Bristol BS8 1SS, UKFrancois Balloux - UCL Genetics Institute, Gower Street, London WC1E 6BT, UKIlán Leboreiro - Instituto Nacional de Antropología e Historia, Moneda 13, Centro, Cuauhtémoc, 06060 Mexico Mexico City, MexicoJose Luis Vera - Escuela Nacional de AntropologÍa e Historia, Periférico Sur y Zapote s/n. Colonia Isidro Fabela, Tlalpan, Isidro Fabela, 14030 Mexico City, MexicoHector Rangel-Villalobos - Instituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, MexicoDavide Pettener - Dipartimento di Scienze Biologiche, Geologiche e Ambientali (BiGeA), Università di Bologna, Via Selmi 3, 40126 Bologna, ItalyDonata Luiselli - Dipartimento di Scienze Biologiche, Geologiche e Ambientali (BiGeA), Università di Bologna, Via Selmi 3, 40126 Bologna, ItalyLoren G Davis - Department of Anthropology, Oregon State University, 238 Waldo Hall, Corvallis, OR, 97331 USAEvelyne Heyer - Museum National d'Histoire Naturelle, CNRS, Université Paris 7 Diderot, Sorbonne Paris Cité, Sorbonne Universités, Unité Eco-Anthropologie et Ethnobiologie (UMR7206), Paris, FranceChristoph P. E Zollikofer - Anthropological Institute and Museum, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, SwitzerlandMarcia S Ponce de León - Anthropological Institute and Museum, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, SwitzerlandColin I Smith - Department of Archaeology and History, La Trobe University, Melbourne, Victoria 3086, AustraliaVaughan Grimes - Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, CanadaKelly-Anne Pike - Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, CanadaMichael Deal - Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, CanadaBenjamin T Fuller - Department of Earth System Science, University of California, Irvine, Keck CCAMS Group, B321 Croul Hall, Irvine, California, 92697, USABernardo Arriaza - Instituto de Alta Investigación, Universidad de Tarapacá, 18 de Septiembre 2222, Carsilla 6-D Arica, ChileVivien Standen - Departamento de Antropologia, Universidad de Tarapacá, 18 de Septiembre 2222. Casilla 6-D Arica, ChileMaria F Luz - Fundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, BrazilFrancois Ricaut - Laboratoire d’Anthropologie Moléculaire et Imagérie de Synthèse UMR-5288, CNRS, Université de Toulouse, 31073 Toulouse, FranceNiede Guidon - Fundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, BrazilLudmila Osipova - Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, RussiaMikhail I Voevoda - Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, RussiaOlga L Posukh - Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, RussiaOleg Balanovsky - Vavilov Institute of General Genetics, Gubkina 3, 119333 Moscow, RussiaMaria Lavryashina - Kemerovo State University, Krasnaya 3, 650000 Kemerovo, RussiaYuri Bogunov - Vavilov Institute of General Genetics, Gubkina 3, 119333 Moscow, RussiaElza Khusnutdinova - Institute of Biochemistry and Genetics, Ufa Scientific Center of RAS, Prospekt Oktyabrya 71, 450054 Ufa, RussiaMarina Gubina - Fundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, BrazilElena Balanovska - Research Centre for Medical Genetics, Moskvorechie 1, 115478 Moscow, RussiaSardana Fedorova - Department of Molecular Genetics, Yakut Scientific Centre of Complex Medical Problems, Sergelyahskoe Shosse 4, 677010 Yakutsk, RussiaSergey Litvinov - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, EstoniaBoris Malyarchuk - Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street 18, Magadan 685000, RussiaMiroslava Derenko - Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street 18, Magadan 685000, RussiaM. J Mosher - Department of Anthropology, Western Washington University, Bellingham Washington 98225, USADavid Archer - Department of Anthropology, Northwest Community College, 353 Fifth Street, Prince Rupert, British Columbia V8J 3L6, CanadaJerome Cybulski - Canadian Museum of History, 100 Rue Laurier, Gatineau, Quebec K1A 0M8, CanadaBarbara Petzelt - Metlakatla Treaty Office, PO Box 224, Prince Rupert, BC, Canada V8J 3P6Joycelynn Mitchell - Metlakatla Treaty Office, PO Box 224, Prince Rupert, BC, Canada V8J 3P6Rosita Worl - Sealaska Heritage Institute, 105 S. Seward Street, Juneau, Alaska 99801, USAPaul J Norman - Department of Structural Biology, Stanford University School of Medicine, D100 Fairchild Science Building, Stanford, California 94305-5126, USAPeter Parham - Department of Structural Biology, Stanford University School of Medicine, D100 Fairchild Science Building, Stanford, California 94305-5126, USABrian M Kemp - School of Biological Sciences, Washington State University, PO Box 644236, Heald 429, Pullman, Washington 99164, USAToomas Kivisild - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, EstoniaChris Tyler-Smith - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UKManjinder S Sandhu - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UKMichael Crawford - Laboratory of Biological Anthropology, University of Kansas, 1415 Jayhawk Blvd., 622 Fraser Hall, Lawrence, Kansas 66045, USARichard Villems - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, EstoniaDavid Glenn Smith - Molecular Anthropology Laboratory, 209 Young Hall, Department of Anthropology, University of California, One Shields Avenue, Davis, California 95616, USAMichael R Waters - Center for the Study of the First Americans, Texas A&M University, College Station, Texas 77843-4352, USATed Goebel - Center for the Study of the First Americans, Texas A&M University, College Station, Texas 77843-4352, USAJohn R Johnson - Santa Barbara Museum of Natural History, 2559 Puesta del Sol, Santa Barbara, CA 93105, USARipan S Malhi - Department of Anthropology, University of Illinois at Urbana-Champaign, 607 S. Mathews Ave, Urbana, IL 61801, USAMattias Jakobsson - Department of Evolutionary Biology and Science for Life Laboratory, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, SwedenDavid J Meltzer - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, DenmarkAndrea Manica - Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UKRichard Durbin - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UKCarlos D Bustamante - Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USAYun S Song - Computer Science Division, University of California, Berkeley, CA 94720, USARasmus Nielsen - Department of Integrative Biology, University of California, 3060 Valley Life Sciences Bldg #3140, Berkeley, CA 94720, USAEske Willerslev - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark
- Publication Details
- Science (American Association for the Advancement of Science), Vol.349(6250), pp.aab3884-aab3884
- Academic Unit
- Biological Sciences, School of
- Identifiers
- 99900547596901842
- Language
- English
- Resource Type
- Journal article