Journal article
Genomic signatures of positive selection in humans and the limits of outlier approaches
Genome Research, Vol.16(8), pp.980-989
08/2006
Handle:
https://hdl.handle.net/2376/105200
PMCID: PMC1524870
PMID: 16825663
Abstract
Identifying regions of the human genome that have been targets of positive selection will provide important insights into recent human evolutionary history and may facilitate the search for complex disease genes. However, the confounding effects of population demographic history and selection on patterns of genetic variation complicate inferences of selection when a small number of loci are studied. To this end, identifying outlier loci from empirical genome-wide distributions of genetic variation is a promising strategy to detect targets of selection. Here, we evaluate the power and efficiency of a simple outlier approach and describe a genome-wide scan for positive selection using a dense catalog of 1.58 million SNPs that were genotyped in three human populations. In total, we analyzed 14,589 genes, 385 of which possess patterns of genetic variation consistent with the hypothesis of positive selection. Furthermore, several extended genomic regions were found, spanning >500 kb, that contained multiple contiguous candidate selection genes. More generally, these data provide important practical insights into the limits of outlier approaches in genome-wide scans for selection, provide strong candidate selection genes to study in greater detail, and may have important implications for disease related research.
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Details
- Title
- Genomic signatures of positive selection in humans and the limits of outlier approaches
- Creators
- Joanna L Kelley - Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USAJennifer Madeoy - Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USAJohn C Calhoun - Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USAWillie Swanson - Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USAJoshua M Akey - Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
- Publication Details
- Genome Research, Vol.16(8), pp.980-989
- Academic Unit
- Kelley Lab; Biological Sciences, School of
- Publisher
- Cold Spring Harbor Laboratory Press
- Identifiers
- 99900546854101842
- Language
- English
- Resource Type
- Journal article