Journal article
Genotoxic modification of nucleic acid bases and biological consequences of it. Review and prospects of experimental and computational investigations
Molekuliarnaia biologiia, Vol.27(4), pp.734-757
07/1993
Handle:
https://hdl.handle.net/2376/112723
PMID: 8361483
Abstract
The review is presented of experimental and computational data on the influence of genotoxic modification of bases (deamination, alkylation, oxidation) on the structure and biological functioning of nucleic acids. Pathways are discussed for the influence of modification on coding properties of bases, on possible errors of nucleic acid biosynthesis, and on configurations of nucleotide mispairs. The atomic structure of nucleic acid fragments with modified bases and the role of base damages in mutagenesis and carcinogenesis are considered.
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Details
- Title
- Genotoxic modification of nucleic acid bases and biological consequences of it. Review and prospects of experimental and computational investigations
- Creators
- V I PoltevV I BruskovN V ShuliupinaR ReinM ShibataR OrnsteinJ Miller
- Publication Details
- Molekuliarnaia biologiia, Vol.27(4), pp.734-757
- Academic Unit
- Engineering and Applied Sciences (TRIC), School of
- Publisher
- Russia (Federation)
- Identifiers
- 99900548342901842
- Language
- Russian
- Resource Type
- Journal article