Journal article
Geographically variable selection in Ambystoma tigrinum virus (Iridoviridae) throughout the western USA
Journal of evolutionary biology, Vol.21(4), pp.1151-1159
07/2008
Handle:
https://hdl.handle.net/2376/101861
PMID: 18444995
Abstract
We investigated spatially variable selection in Ambystoma tigrinum virus (ATV) which causes frequent and geographically widespread epizootics of the tiger salamander, Ambystoma tigrinum. To test for evidence of selection, we sequenced several coding and noncoding regions from virus strains isolated from epizootics throughout western North America. Three of the sequenced regions contained homologues for genes putatively involved in host immune evasion and virulence: eIF-2alpha, caspase activation and recruitment domain (CARD) and beta-OH-steroid oxidoreductase. Selection analysis showed evidence of very strong purifying selection on eIF-2alpha, purifying selection within certain viral clades on CARD and positive selection on beta-OH-steroid oxidoreductase within certain clades. Analysis using MULTIDIVTIME and Tajima's relative rate tests indicate accelerated rates of evolution within clades associated with anthropogenic movement. These clades also demonstrate greater spatial variability in selection, suggesting a lack of local adaptation (i.e. locally adapted populations should exhibit little to no selection because of absent or reduced variation in fitness once a fitness optimum is reached). Increased transfer of non-native viral strains to naïve salamander populations, in conjunction with local maladaptation as a result of local selection pressures, may explain the spread and emergence of ATV epizootics in A. tigrinum in western North America.
Metrics
15 Record Views
Details
- Title
- Geographically variable selection in Ambystoma tigrinum virus (Iridoviridae) throughout the western USA
- Creators
- B J Ridenhour - School of Biological Sciences, Washington State University, Pullman, WA, USA. bridenho@uidaho.eduA T Storfer
- Publication Details
- Journal of evolutionary biology, Vol.21(4), pp.1151-1159
- Academic Unit
- Biological Sciences, School of
- Publisher
- Switzerland
- Identifiers
- 99900546554801842
- Language
- English
- Resource Type
- Journal article