Journal article
Glucose Oxidase-Integrated Metal-Organic Framework Hybrids as Biomimetic Cascade Nanozymes for Ultrasensitive Glucose Biosensing
ACS applied materials & interfaces, Vol.11(25), pp.22096-22101
06/26/2019
PMID: 31134797
Abstract
Nanozyme/natural enzyme hybrid plays a vital role in biosensing, therapy, and catalysis owing to the integrated advantages in the selectivity of natural enzymes and controllable catalytic activity of nanozymes. Herein, Fe-MIL-88B-NH2 [(Fe-metal organic framework (MOF)] with remarkable peroxidase-like activity, ultrahigh stability, and high biocompatibility was utilized for immobilization of glucose oxidase (GOx) via an amidation coupling reaction. On the basis of the excellent selectivity and catalytic activity of Fe-MOF-GOx, a cascade catalysis was performed for the colorimetric detection of glucose. The integrated Fe-MOF-GOx not only exhibited higher stability and reusability than their mixtures including Fe-MOF and free GOx system but also possessed a wide linear range (1-500 mu M), with a low detection limit of 0.487 mu M for glucose detection.
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Details
- Title
- Glucose Oxidase-Integrated Metal-Organic Framework Hybrids as Biomimetic Cascade Nanozymes for Ultrasensitive Glucose Biosensing
- Creators
- Weiqing Xu - Central China Normal UniversityLei Jiao - Central China Normal UniversityHongye Yan - Central China Normal UniversityYu Wu - Central China Normal UniversityLijuan Chen - Henan Provincial People's HospitalWenling Gu - Central China Normal UniversityDan Du - Washington State UniversityYuehe Lin - Washington State UniversityChengzhou Zhu - Central China Normal University
- Publication Details
- ACS applied materials & interfaces, Vol.11(25), pp.22096-22101
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Amer Chemical Soc
- Number of pages
- 6
- Grant note
- Recruitment Program of Global Youth Experts of China B17019 / Program of Introducing Talents of Discipline to Universities of China (111 program) CCNU19QN066 / Fundamental Research Funds for the Central Universities
- Identifiers
- 99901227646101842
- Language
- English
- Resource Type
- Journal article