Journal article
Graphene loaded bimetallic Au@Pt nanodendrites enhancing ultrasensitive electrochemical immunoassay of AFP
Sensors and actuators. B, Chemical, Vol.231, pp.513-519
08/2016
Abstract
A dual enhancing strategy has been employed to develop electrochemical immunosensor for the ultrasensitive detection of AFP, which is enhanced by poly-dopamine functionalized N-doped multi-walled carbon nanotube (PDA-N-MWCNT) and the nanocomposite of graphene loaded Au@Pt mesoporous nanodendrites. The fabricated immunosensor exhibited a wide linear range of 0.1pg/mL–10ng/mL, with an ultralow detection limit of 0.05pg/mL. The good performance of the developed immunosensor could be contributed to (1) PDA-N-MWCNT supplied good biocompatible surface for immobilizing primary antibody (Ab1); (2) PDA-N-MWCNT modified electrode endowed more electrochemical active area, which can effectively improve the sensitivity of the immunosensor; (3) graphene could load high amount of good conductive and high electrocatalytic active Au@Pt nanodendrites for signal amplification. The results imply that the as-fabricated immunosensors have great potential for clinic usage.
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Details
- Title
- Graphene loaded bimetallic Au@Pt nanodendrites enhancing ultrasensitive electrochemical immunoassay of AFP
- Creators
- Lei Jiao - University of JinanZonggang Mu - University of JinanChengzhou Zhu - Washington State UniversityQin Wei - University of JinanHe Li - University of JinanDan Du - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- Sensors and actuators. B, Chemical, Vol.231, pp.513-519
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Elsevier B.V
- Number of pages
- 7
- Identifiers
- 99901227646301842
- Language
- English
- Resource Type
- Journal article