Journal article
Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.293(2), pp.R922-930
08/2007
Handle:
https://hdl.handle.net/2376/112457
PMID: 17537840
Abstract
Growth hormone-releasing hormone (GHRH), its receptor (GHRHR), and other members of the somatotropic axis are involved in non-rapid eye movement sleep (NREMS) regulation. Previously, studies established the involvement of hypothalamic GHRHergic mechanisms in NREMS regulation, but cerebral cortical GHRH mechanisms in sleep regulation remained uninvestigated. Here, we show that unilateral application of low doses of GHRH to the surface of the rat somatosensory cortex ipsilaterally decreased EEG delta wave power, while higher doses enhanced delta power. These actions of GHRH on EEG delta wave power occurred during NREMS but not during rapid eye movement sleep. Further, the cortical forms of GHRH and GHRHR were identical to those found in the hypothalamus and pituitary, respectively. Cortical GHRHR mRNA and protein levels did not vary across the day-night cycle, whereas cortical GHRH mRNA increased with sleep deprivation. These results suggest that cortical GHRH and GHRHR have a role in the regulation of localized EEG delta power that is state dependent, as well as in their more classic hypothalamic role in NREMS regulation.
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Details
- Title
- Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression
- Creators
- Eva Szentirmai - Washington State University, College of Veterinary Medicine, Program in Neuroscience, Pullman, WA 99164-6520, USATadanobu YasudaPing TaishiMingxiang WangLynn ChurchillStewart BohnetPaul MagrathBálint KacsóhLissette JimenezJames M Krueger
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.293(2), pp.R922-930
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- NS27250 / NINDS NIH HHS NS25378 / NINDS NIH HHS
- Identifiers
- 99900548082501842
- Language
- English
- Resource Type
- Journal article