Journal article
Growth-hormone-releasing hormone mediates the sleep-promoting activity of interleukin-1 in rats
Neuroendocrinology, Vol.61(5), pp.559-565
05/1995
Handle:
https://hdl.handle.net/2376/106115
PMID: 7617134
Abstract
The involvement of endogenous growth-hormone-releasing hormone (GHRH) in the sleep-promoting activity of interleukin-1 (IL1) was studied. The effects on sleep of intracerebroventricular injection of IL1 were tested in rats pretreated with intracerebroventricular antibodies to GHRH (GHRH-ab). One group of rats received two treatments each consisting of two injections, control IgG + physiological saline (IgG + Sal) and on another day GHRH-ab + Sal, whereas another group of rats received IgG + Sal, IgG + IL1 and GHRH-ab + IL1 on separate days with one day off between the various treatments. IgG or GHRH-ab was injected 6 h prior to dark onset; Sal or IL1 was administered at dark onset. Recording of sleep-wake activity and cortical brain temperature (Tcrt) was started with the injection of IgG or GHRH-ab and continued for 18 h. GHRH-ab (GHRH-ab + Sal) suppressed rapid eye movement sleep (REMS), non-REMS (NREMS) and EEG slow-wave activity (SWA) during NREMS throughout the recording period. IL1 treatment (IgG + IL1) enhanced NREMS and SWA, and induced fever for 6 h. Pretreatment with GHRH-ab (GHRH-ab + IL1) abolished the IL1-induced increases in NREMS, attenuated the enhancements in SWA, and suppressed fever for 6 hours after IL1. The results indicate that the sleep-promoting activity of IL1 is mediated at least in part via GHRH. The suppression of the IL1-induced fever by GHRH-ab might be attributed to an inhibition of hypothalamic somatostatin.
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Details
- Title
- Growth-hormone-releasing hormone mediates the sleep-promoting activity of interleukin-1 in rats
- Creators
- F Obál, Jr - Department of Physiology, A. Szent-Györgyi Medical School, Szeged, HungaryJ FangL C PayneJ M Krueger
- Publication Details
- Neuroendocrinology, Vol.61(5), pp.559-565
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Switzerland
- Grant note
- NS-25378 / NINDS NIH HHS NS-27250 / NINDS NIH HHS
- Identifiers
- 99900546812101842
- Language
- English
- Resource Type
- Journal article