Journal article
Hepatic cortisol sulfotransferase activity in several types of experimental hypertension in male rats
Biochemical pharmacology, Vol.26(11), pp.1033-1038
1977
Handle:
https://hdl.handle.net/2376/116243
PMID: 880255
Abstract
The relationship between hepatic cortisol sulfotransferase activity (HCSA) and several types of hypertension was examined in male rats. It was found that development of Grollman hypertension was paralleled by increased HCSA. The maximum blood pressure differences observed between experimental animals and controls, in individual experiments, were 83 and 95 mm. accompanied by 138 and 124% HCSA increases. HCSA was also elevated significantly, compared to controls, in spontaneously hypertensive Okamoto rats (SHR) and in hypertension elicited in intact or Grollman operated rats by daily, intramuscular injection of 0.6 mg of FLHC (9α-nuoro-11 β, 17α, 21-trihydroxy-pregn-4-ene-3, 20-dione) for 30–45 days. HCSA increased 47 and 152% in SHR and in FLHC treated animals respectively. Blood pressures were elevated 40–60 mm in both cases. Grollman operated animals given FLHC exhibited higher blood pressures than did intact animals. Administration of cortisol (6 mg) and corticosterone (3 mg) also caused hypertension in intact rats. This was accompanied by elevated HCSA. Deoxycorticosterone (3 mg) caused hypertension only in animals restricted to drinking 1% saline. This hypertension was also accompanied by elevated HCSA. Conditions or steroid concentrations that did not result in hypertension did not elevate HCSA significantly. The increased HCSA in all the types of hypertension studied was largely due to STIII. the major glucocorticoid sulfotransferase of livers from male rats.
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Details
- Title
- Hepatic cortisol sulfotransferase activity in several types of experimental hypertension in male rats
- Creators
- Sanford S SingerEdward HessStephen Sylvester
- Publication Details
- Biochemical pharmacology, Vol.26(11), pp.1033-1038
- Publisher
- Elsevier Inc
- Identifiers
- 99900547675401842
- Language
- English
- Resource Type
- Journal article