Journal article
Herpesvirus Entry into Host Cells Mediated by Endosomal Low pH
Traffic (Copenhagen, Denmark), Vol.17(9), pp.965-975
09/2016
Handle:
https://hdl.handle.net/2376/107163
PMCID: PMC5444542
PMID: 27126894
Abstract
Herpesviral pathogenesis stems from infection of multiple cell types including the site of latency and cells that support lytic replication. Herpesviruses utilize distinct cellular pathways, including low pH endocytic pathways, to enter different pathophysiologically relevant target cells. This review details the impact of the mildly acidic milieu of endosomes on the entry of herpesviruses, with particular emphasis on herpes simplex virus 1 (HSV-1). Epithelial cells, the portal of primary HSV-1 infection, support entry via low pH endocytosis mechanisms. Mildly acidic pH triggers reversible conformational changes in the HSV-1 class III fusion protein glycoprotein B (gB). In vitro treatment of herpes simplex virions with a similar pH range inactivates infectivity, likely by prematurely activating the viral entry machinery in the absence of a target membrane. How a given herpesvirus mediates both low pH and pH-independent entry events is a key unresolved question.
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Details
- Title
- Herpesvirus Entry into Host Cells Mediated by Endosomal Low pH
- Creators
- Anthony V Nicola - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164, USA
- Publication Details
- Traffic (Copenhagen, Denmark), Vol.17(9), pp.965-975
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- England
- Grant note
- R01 AI119159 / NIAID NIH HHS
- Identifiers
- 99900546762701842
- Language
- English
- Resource Type
- Journal article