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CC BY V4.0, Open Access
Journal article
Hes6 Controls Cell Proliferation via Interaction with cAMP-response Element-binding Protein-binding Protein in the Promyelocytic Leukemia Nuclear Body
The Journal of biological chemistry, Vol.283(9), pp.5939-5949
02/29/2008
PMID: 18160400
Abstract
Hes6 is a basic helix-loop-helix transcription factor that functions in the differentiation of pluripotent progenitor cells and during tumorigenesis. However, the molecular mechanism for its function is largely unknown. Here we show that Hes6 is a component of the promyelocytic leukemia nuclear body (PML-NB) complex in the nuclei and that Hes6 inhibits cell proliferation through induction of p21 cyclin-dependent kinase inhibitor. We further show that Hes6 directly interacts with CREB-binding protein (CBP), one of the key components of PML-NB, via its basic domain. This association is critical for p21 induction through multiple mechanisms, including chromatin remodeling and p53 acetylation. Taken together, these results suggest that the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways.
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Details
- Title
- Hes6 Controls Cell Proliferation via Interaction with cAMP-response Element-binding Protein-binding Protein in the Promyelocytic Leukemia Nuclear Body
- Creators
- Bokkee Eun - Seoul National UniversityYool Lee - Washington State University, Biomedical Sciences, Department ofSoontaek Hong - Korea UniversityJaesang Kim - Ewha Womans UniversityHan-Woong Lee - Yonsei UniversityKyungjin Kim - Daegu Gyeongbuk Institute of Science and TechnologyWoong Sun - Korea UniversityHyun Kim - Korea University
- Publication Details
- The Journal of biological chemistry, Vol.283(9), pp.5939-5949
- Academic Unit
- Elson S. Floyd College of Medicine
- Publisher
- Elsevier Inc
- Identifiers
- 99901132534701842
- Language
- English
- Resource Type
- Journal article