Journal article
Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids
ACS materials letters, Vol.3(4), pp.420-427
04/05/2021
Abstract
Free-standing two-dimensional (2D) organic nanomaterials are highly attractive for biological applications because of their unique structural properties and high biocompatibility. Herein, we designed and synthesized a new class of highly bright and photostable membrane-mimetic 2D nanosheets from sequence-defined peptoids. These nanosheets exhibited high quantum yield and photostability as a result of the precise placement and ordering of dansyl dye molecules within crystalline nanosheets. We further showed the use of these nanosheets as biocompatible and programmable probes for live cell imaging and cell labeling. By programing these nanosheets with different surface charges, we achieved the enhanced lysosome escape of these nanosheets, showing their great potential as nanocarriers for the efficient intracellular delivery of macromolecular drugs.
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Details
- Title
- Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids
- Creators
- Yang Song - Washington State UniversityMingming Wang - Pacific Northwest National LaboratorySusrut Akkineni - Pacific Northwest National LaboratoryWenchao Yang - Pacific Northwest National LaboratoryJeevapani J. Hettige - Pacific Northwest National LaboratoryHaibao Jin - Pacific Northwest National LaboratoryZhihao Liao - Pacific Northwest National LaboratoryPeng Mu - Pacific Northwest National LaboratoryFeng Yan - Pacific Northwest National LaboratoryMarcel Baer - Pacific Northwest National LaboratoryJames J. De Yoreo - Pacific Northwest National LaboratoryDan Du - Washington State UniversityYuehe Lin - Washington State UniversityChun-Long Chen - Pacific Northwest Natl Lab, Div Phys Sci, Richland, WA 99352 USA
- Publication Details
- ACS materials letters, Vol.3(4), pp.420-427
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Amer Chemical Soc
- Number of pages
- 8
- Grant note
- Materials Synthesis and Simulation Across Scales Initiative through the Laboratory Directed Research and Development program at PNNL DE-AC02-05CH11231 / US DOE OBES Scientific User Facilities Division; United States Department of Energy (DOE) U.S. Department of Energy (DOE), Office of Basic Energy Sciences (OBES), Biomolecular Materials Program at Pacific Northwest National Laboratory (PNNL); United States Department of Energy (DOE) Washington State University DEAC05-76RL01830 / Department of Energy; United States Department of Energy (DOE)
- Identifiers
- 99901227641301842
- Language
- English
- Resource Type
- Journal article