Journal article
Highly Selective Fluorescence off-on Probes for Biothiols and Imaging in Live Cells
Organic & biomolecular chemistry, Vol.12(35), pp.6837-6841
09/21/2014
Handle:
https://hdl.handle.net/2376/107740
PMCID: PMC4134666
PMID: 25047799
Abstract
Three sulfonyl benzothiazole-based fluorescent probes (
RSHP1
,
RSHP2
, and
RSHP3
) for the detection of biothiols (cysteine, homocysteine, and glutathione) are developed based on thiol-mediated nucleophilic aromatic substitutions. The probes exhibited good selectivity and sensitivity toward biothiols over other analytes. The probes were successfully applied for visualizing endogenous thiols in living cells.
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Details
- Title
- Highly Selective Fluorescence off-on Probes for Biothiols and Imaging in Live Cells
- Creators
- Di Zhang - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, China. Tel: +86-371-67767051Wei Chen - Department of Chemistry, Washington State University, Pullman, WA 99164, USA. Fax: +1- 509-335-8867Jianming Kang - Department of Chemistry, Washington State University, Pullman, WA 99164, USA. Fax: +1- 509-335-8867Yong Ye - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, China. Tel: +86-371-67767051Yufen Zhao - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, China. Tel: +86-371-67767051Ming Xian - Department of Chemistry, Washington State University, Pullman, WA 99164, USA. Fax: +1- 509-335-8867
- Publication Details
- Organic & biomolecular chemistry, Vol.12(35), pp.6837-6841
- Academic Unit
- Chemistry, Department of
- Identifiers
- 99900547472201842
- Language
- English
- Resource Type
- Journal article