Journal article
Highly stable and sensitive fluorescent probes (LysoProbes) for lysosomal labeling and tracking
Scientific reports, Vol.5(1), pp.8576-8576
02/26/2015
Handle:
https://hdl.handle.net/2376/107766
PMCID: PMC4341211
PMID: 25715948
Abstract
We report the design, synthesis and application of several new fluorescent probes (LysoProbes I-VI) that facilitate lysosomal pH monitoring and characterization of lysosome-dependent apoptosis. LysoProbes are superior to commercially available lysosome markers since the fluorescent signals are both stable and highly selective, and they will aid in characterization of lysosome morphology and trafficking. We predict that labeling of cancer cells and solid tumor tissues with LysoProbes will provide an important new tool for monitoring the role of lysosome trafficking in cancer invasion and metastasis.
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Details
- Title
- Highly stable and sensitive fluorescent probes (LysoProbes) for lysosomal labeling and tracking
- Creators
- Nazmiye B Yapici - Department of Chemistry, Michigan Technological University, Houghton, MI 49931Yue Bi - Second Hospital of HeBei Medical University, Shijiazhuang, China 050000Pengfei Li - Second Hospital of HeBei Medical University, Shijiazhuang, China 050000Xin Chen - Department of Chemistry, Michigan Technological University, Houghton, MI 49931Xin Yan - Department of Chemistry, Michigan Technological University, Houghton, MI 49931Srinivas Rao Mandalapu - Department of Chemistry, Michigan Technological University, Houghton, MI 49931Megan Faucett - Department of Chemistry, Michigan Technological University, Houghton, MI 49931Steffen Jockusch - Department of Chemistry, Columbia University, NY 10027Jingfang Ju - Translational Research Laboratory, Stony Brook Medicine, Stony Brook, NY 11794K Michael Gibson - Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane WA 99202William J Pavan - National Human Genome Research Institute, NIH, Bethesda, Maryland 20892Lanrong Bi - Department of Chemistry, Michigan Technological University, Houghton, MI 49931
- Publication Details
- Scientific reports, Vol.5(1), pp.8576-8576
- Academic Unit
- Pharmacotherapy, Department of
- Publisher
- England
- Grant note
- R15 GM088795 / NIGMS NIH HHS GM088795-01 / NIGMS NIH HHS
- Identifiers
- 99900546823701842
- Language
- English
- Resource Type
- Journal article