Journal article
Homeostatic Synapse-Driven Membrane Plasticity in Nucleus Accumbens Neurons
The Journal of neuroscience, Vol.29(18), pp.5820-5831
05/06/2009
Handle:
https://hdl.handle.net/2376/108524
PMCID: PMC2743333
PMID: 19420249
Abstract
Stable brain function relies on homeostatic maintenance of the functional output of individual neurons. In general, neurons function by converting synaptic input to output as action potential firing. To determine homeostatic mechanisms that balance this input–output/synapse–membrane interaction, we focused on nucleus accumbens (NAc) neurons and demonstrated a novel form of synapse-to-membrane homeostatic regulation, homeostatic synapse-driven membrane plasticity (
h
SMP). Through
h
SMP, NAc neurons adjusted their membrane excitability to functionally compensate for basal shifts in excitatory synaptic input. Furthermore,
h
SMP was triggered by synaptic NMDA receptors (NMDARs) and expressed by the modification of SK-type Ca
2+
-activated potassium channels. Moreover,
h
SMP in NAc neurons was abolished in rats during a short- (2 d) or long- (21 d) term withdrawal from repeated intraperitoneal injections of cocaine (15 mg/kg/d, 5 d). These results suggest that
h
SMP is a novel form of synapse-to-membrane homeostatic plasticity and dysregulation of
h
SMP may contribute to cocaine-induced cellular alterations in the NAc.
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Details
- Title
- Homeostatic Synapse-Driven Membrane Plasticity in Nucleus Accumbens Neurons
- Creators
- Masago Ishikawa - Program in Neuroscience andPing Mu - Program in Neuroscience andJason T Moyer - Departments ofJohn A Wolf - Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104Raymond M Quock - Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164-6520Neal M Davies - Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164-6520Xiu-ti Hu - Department of Pharmacology, Rush University, Chicago, Illinois 60612, andOliver M Schlüter - Department of Molecular Neurobiology, European Neuroscience Institute, 37077 Göttingen, GermanyYan Dong - Program in Neuroscience and
- Publication Details
- The Journal of neuroscience, Vol.29(18), pp.5820-5831
- Academic Unit
- Psychology, Department of
- Publisher
- Society for Neuroscience
- Identifiers
- 99900547519301842
- Language
- English
- Resource Type
- Journal article