Journal article
Host–microbe interaction systems biology: lifecycle transcriptomics and comparative genomics
Future microbiology, Vol.5(2), pp.205-219
02/2010
Handle:
https://hdl.handle.net/2376/105069
PMCID: PMC2846718
PMID: 20143945
Abstract
The use of microarray and comparative genomic technologies for the analysis of host–pathogen interactions has led to a greater understanding of the biological systems involved in infectious disease processes. Transcriptome analysis of intracellular pathogens at single or multiple time points during infection offers insight into the pathogen intracellular lifecycle. Host–pathogen transcriptome analysis
in vivo
, over time, enables characterization of both the pathogen and the host during the dynamic, multicellular host response. Comparative genomics using hybridization microarray-based comparative whole-genome resequencing or
de novo
whole-genome sequencing can identify the genetic factors responsible for pathogen evolutionary divergence, emergence, reemergence or the genetic basis for different pathogenic phenotypes. Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease.
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Details
- Title
- Host–microbe interaction systems biology: lifecycle transcriptomics and comparative genomics
- Creators
- Daniel E Sturdevant - Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 363 9248, Fax: +1 406 363 9427Kimmo Virtaneva - Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 363 9430, Fax: +1 406 363 9427Craig Martens - Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 363 9430, Fax: +1 406 363 9415Daniel Bozinov - Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 375 7444, Fax: +1 406 363 9415Olajumoke M Ogundare - Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 375 9744, Fax: +1 406 363 9415Nina Castro - Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 375 9744, Fax: +1 406 363 9415Kishore Kanakabandi - Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 375 9744, Fax: +1 406 363 9415Paul A Beare - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 375 9671, Fax: +1 406 375 9380Anders Omsland - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 375 9656, Fax: +1 406 375 9380John H Carlson - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 363 9296, Fax: +1 406 375 9380Adam D Kennedy - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 363 9439, Fax: +1 406 375 9394Robert A Heinzen - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 375 9695, Fax: +1 406 375 9380Jean Celli - Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 375 9713, Fax: +1 406 375 9640David E Greenberg - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, 33 North Dr., Room 2W10A.3, Bethesda, MD 20892, USA, Tel.: +1 301 402 6923, Fax: +1 310 480 4506Frank R Deleo - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 363 9448, Fax: +1 406 375 9394Stephen F Porcella - Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA, Tel.: +1 406 363 9271, Fax: +1 406 363 9415
- Publication Details
- Future microbiology, Vol.5(2), pp.205-219
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Identifiers
- 99900546774401842
- Language
- English
- Resource Type
- Journal article