Human aneuploidy: mechanisms and new insights into an age-old problem

So I Nagaoka; Terry J Hassold; Patricia A Hunt

doi:10.1038/nrg3245

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Human aneuploidy: mechanisms and new insights into an age-old problem

Journal article

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Human aneuploidy: mechanisms and new insights into an age-old problem

So I Nagaoka, Terry J Hassold and Patricia A Hunt

Nature reviews. Genetics, Vol.13(7), pp.493-504

06/18/2012

DOI: https://doi.org/10.1038/nrg3245

Handle:

https://hdl.handle.net/2376/108148

PMCID: PMC3551553

PMID: 22705668

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Abstract

Meiosis - physiology

Age Factors

Oogenesis - physiology

Humans

Aneuploidy

Oogenesis - genetics

Reproductive Techniques, Assisted

Endocrine Disruptors - adverse effects

Meiosis - genetics

Sex Factors

Chromosome Segregation - physiology

Female

M Phase Cell Cycle Checkpoints - physiology

Trisomic and monosomic (aneuploid) embryos account for at least 10% of human pregnancies and, for women nearing the end of their reproductive lifespan, the incidence may exceed 50%. The errors that lead to aneuploidy almost always occur in the oocyte but, despite intensive investigation, the underlying molecular basis has remained elusive. Recent studies of humans and model organisms have shed new light on the complexity of meiotic defects, providing evidence that the age-related increase in errors in the human female is not attributable to a single factor but to an interplay between unique features of oogenesis and a host of endogenous and exogenous factors.

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Title: Human aneuploidy: mechanisms and new insights into an age-old problem
Creators: So I Nagaoka - School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA
Terry J Hassold
Patricia A Hunt
Publication Details: Nature reviews. Genetics, Vol.13(7), pp.493-504
Academic Unit: Molecular Biosciences, School of
Publisher: England
Grant note: R01 ES013527 / NIEHS NIH HHS T32 GM008336 / NIGMS NIH HHS ES013527 / NIEHS NIH HHS HD21341 / NICHD NIH HHS R01 HD021341 / NICHD NIH HHS R37 HD021341 / NICHD NIH HHS
Identifiers: 99900547031301842
Language: English
Resource Type: Journal article