Journal article
Huperzine A from Huperzia species—An ethnopharmacolgical review
Journal of ethnopharmacology, Vol.113(1), pp.15-34
2007
Handle:
https://hdl.handle.net/2376/116010
PMID: 17644292
Abstract
Huperzine A (HupA), isolated originally from a traditional Chinese medicine
Qiang Ceng Ta, whole plant of
Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (
Huperzia and
Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented.
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Details
- Title
- Huperzine A from Huperzia species—An ethnopharmacolgical review
- Creators
- Xiaoqiang Ma - State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR ChinaChangheng Tan - State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR ChinaDayuan Zhu - State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR ChinaDavid R Gang - Department of Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes Building, Tucson, AZ 85721-0036, USAPeigen Xiao - Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100094, PR China
- Publication Details
- Journal of ethnopharmacology, Vol.113(1), pp.15-34
- Academic Unit
- Biological Chemistry, Institute of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900547875901842
- Language
- English
- Resource Type
- Journal article