Journal article
Hyaluronic Acid-Modified Multifunctional Q-Graphene for Targeted Killing of Drug-Resistant Lung Cancer Cells
ACS applied materials & interfaces, Vol.8(6), pp.4048-4055
02/17/2016
Handle:
https://hdl.handle.net/2376/101926
PMID: 26785717
Abstract
Considering the urgent need to explore multifunctional drug delivery system for overcoming multidrug resistance, we prepared a new nanocarbon material Q-Graphene as a nanocarrier for killing drug-resistant lung cancer cells. Attributing to the introduction of hyaluronic acid and rhodamine B isothiocyanate (RBITC), the Q-Graphene-based drug delivery system was endowed with dual function of targeted drug delivery and fluorescence imaging. Additionally, doxorubicin (DOX) as a model drug was loaded on the surface of Q-Graphene via π-π stacking. Interestingly, the fluorescence of DOX was quenched by Q-Graphene due to its strong electron-accepting capability, and a significant recovery of fluorescence was observed, while DOX was released from Q-Graphene. Because of the RBITC labeling and the effect of fluorescence quenching/restoring of Q-Graphene, the uptake of nanoparticles and intracellular DOX release can be tracked. Overall, a highly promising multifunctional nanoplatform was developed for tracking and monitoring targeted drug delivery for efficiently killing drug-resistant cancer cells.
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Details
- Title
- Hyaluronic Acid-Modified Multifunctional Q-Graphene for Targeted Killing of Drug-Resistant Lung Cancer Cells
- Creators
- Yanan Luo - Paul G. Allen School for Global Animal Health, Washington State University , PO Box 647090 Pullman, Washington 99164, United StatesXiaoli Cai - Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. ChinaHe Li - School of Mechanical and Materials Engineering, Washington State University , PO Box 642920 Pullman, Washington 99164, United StatesYuehe Lin - Paul G. Allen School for Global Animal Health, Washington State University , PO Box 647090 Pullman, Washington 99164, United StatesDan Du - Paul G. Allen School for Global Animal Health, Washington State University , PO Box 647090 Pullman, Washington 99164, United States
- Publication Details
- ACS applied materials & interfaces, Vol.8(6), pp.4048-4055
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- United States
- Grant note
- R21OH010768 / NIOSH CDC HHS
- Identifiers
- 99900546531501842
- Language
- English
- Resource Type
- Journal article