Journal article
Hypotensive effects of sarthran in normotensive and spontaneously hypertensive rat strains
Pharmacology, biochemistry and behavior, Vol.39(4), pp.1029-1032
1991
Handle:
https://hdl.handle.net/2376/115207
PMID: 1763099
Abstract
The specific angiotensin receptor antagonist [Sar
1, Thr
8]AII (sarthran) was intracerebroventricularly (ICV) infused in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) normotensive controls. The results extend earlier findings by determining that: 1) the hypotensive effect of ICV-infused sarthran could be enhanced in anesthetized as compared with alert animals; 2) SHRs revealed a greater hypotensive response as compared with WKY rats; and 3) no sarthran-induced agonistic effects were observed in contrast with previous results using alert SHRs. These findings support the use of sarthran as a potent angiotensin receptor antagonist to investigate the role of the brain angiotensin system in the control of normal and dysfunctional blood pressure.
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Details
- Title
- Hypotensive effects of sarthran in normotensive and spontaneously hypertensive rat strains
- Creators
- Cathy E MurrayJoseph W HardingJohn W Wright
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.39(4), pp.1029-1032
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900548123101842
- Language
- English
- Resource Type
- Journal article