Journal article
IL-6-trans-signalling increases rapid-eye-movement sleep in rats
European journal of pharmacology, Vol.613(1), pp.141-145
2009
Handle:
https://hdl.handle.net/2376/107412
PMCID: PMC5410711
PMID: 19383497
Abstract
Interleukin 6 (IL-6), a cytokine of the gp130-signalling-family, plays an important role in immediate immunological functions, in metabolism and in the central nervous system. IL-6-signalling is mediated by classic-signalling via the membrane bound IL-6 receptor or by IL-6-trans-signalling via the soluble IL-6 receptor. Whereas the receptor subunit gp130 is ubiquitously expressed within the body, IL-6 receptor expression is restricted to distinct cell populations. Within the brain parenchyma the IL-6 receptor is sparsely expressed, and therefore the brain is mostly dependent on IL-6-trans-signalling in its response to IL-6. Recently we have shown that IL-6-trans-signalling but not classic-signalling plays a pivotal role in the establishment and maintenance of chronic inflammation and cancer, whereas its role in sleep regulation has not been studied so far. We reasoned that the IL-6-trans-signalling mimetic Hyper-IL-6 which in contrast to IL-6 alone can activate almost all cells of the brain might have a profound effect on sleep regulation and performed sleep recordings with rats injected with recombinant Hyper-IL-6. In the present study, the i.c.v. administration of the designer cytokine Hyper-IL-6 into rats at dark onset increased the amount of rapid-eye-movement sleep (REM sleep) but did not affect non-rapid-eye-movement sleep (non-REM sleep). Our data define a new role of IL-6-trans-signalling in sleep regulation.
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Details
- Title
- IL-6-trans-signalling increases rapid-eye-movement sleep in rats
- Creators
- Ulrike May - Biochemisches Institut, Christian-Albrechts-Universität zu Kiel, Olshausenstraße 40, D-24098, Kiel, GermanyThomas Schiffelholz - Department of Psychiatry and Psychotherapy, Christian-Albrechts-Universität zu Kiel, Niemannsweg 147, 24105 Kiel, GermanyPaul Christian Baier - Department of Psychiatry and Psychotherapy, Christian-Albrechts-Universität zu Kiel, Niemannsweg 147, 24105 Kiel, GermanyJames M Krueger - Department of VCAPP, Program in Neuroscience, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164-6520, USAStefan Rose-John - Biochemisches Institut, Christian-Albrechts-Universität zu Kiel, Olshausenstraße 40, D-24098, Kiel, GermanyJürgen Scheller - Biochemisches Institut, Christian-Albrechts-Universität zu Kiel, Olshausenstraße 40, D-24098, Kiel, Germany
- Publication Details
- European journal of pharmacology, Vol.613(1), pp.141-145
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546898201842
- Language
- English
- Resource Type
- Journal article