Files and links (1)
CC BY V4.0, Open Access
Journal article
Identification of Anaplasma marginale type IV secretion system effector proteins
PloS one., Vol.6(11), p.e7724
11/2011
Handle:
https://hdl.handle.net/2376/5997
Abstract
Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne pathogen and the leading cause of anaplasmosis in cattle worldwide. Complete genome sequencing of A. marginale revealed that it has a type IV secretion system (T4SS). The T4SS is one of seven known types of secretion systems utilized by bacteria, with the type III and IV secretion systems particularly prevalent among pathogenic Gram-negative bacteria. The T4SS is predicted to play an important role in the invasion and pathogenesis of A. marginale by translocating effector proteins across its membrane into eukaryotic target cells. However, T4SS effector proteins have not been identified and tested in the laboratory until now.
Metrics
42 File views/ downloads
64 Record Views
Details
- Title
- Identification of Anaplasma marginale type IV secretion system effector proteins
- Creators
- Svetlana Lockwood (Author)Daniel E Voth (Author)Kelly A. Brayton (Author)Paul A Beare (Author)Wendy C Brown (Author)Robert A Heinzen (Author)Shira L Broschat (Author)
- Publication Details
- PloS one., Vol.6(11), p.e7724
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Electrical Engineering and Computer Science, School of; Paul G. Allen School for Global Animal Health
- Identifiers
- 99900502855601842
- Copyright
- Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/
- Language
- English
- Resource Type
- Journal article