Journal article
Identification of Specific Gene Sequences Conserved in Contemporary Epidemic Strains of Salmonella enterica
Applied and environmental microbiology, Vol.72(11), pp.6938-6947
11/2006
Handle:
https://hdl.handle.net/2376/116817
PMCID: PMC1636165
PMID: 16963552
Abstract
Genetic elements specific to recent and contemporary epidemic strains of
Salmonella enterica
were identified using comparative genomic analysis. Two epidemic multidrug-resistant (MDR) strains, MDR
Salmonella enterica
serovar Typhimurium definitive phage type 104 (DT104) and cephalosporin-resistant MDR
Salmonella enterica
serovar Newport, and an epidemic pansusceptible strain,
Salmonella
serovar Typhimurium DT160, were subjected to
Salmonella
gene microarray and suppression subtractive hybridization analyses. Their genome contents were compared with those of coexisting sporadic strains matched by serotype, geographic and temporal distribution, and host species origin. These paired comparisons revealed that epidemic strains of
S. enterica
had specific genes and gene regions that were shared by isolates of the same subtype. Most of these gene sequences are related to mobile genetic elements, including phages, plasmids, and plasmid-like and transposable elements, and some genes may encode proteins conferring growth or survival advantages. The emergence of epidemic MDR strains may therefore be associated with the presence of fitness-associated genetic factors in addition to their antimicrobial resistance genes.
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Details
- Title
- Identification of Specific Gene Sequences Conserved in Contemporary Epidemic Strains of Salmonella enterica
- Creators
- Min-Su Kang - Department of Veterinary Microbiology and PathologyThomas E Besser - Department of Veterinary Microbiology and PathologyDale D Hancock - Department of Veterinary Microbiology and PathologySteffen Porwollik - Department of Veterinary Microbiology and PathologyMichael McClelland - Department of Veterinary Microbiology and PathologyDouglas R Call - Department of Veterinary Microbiology and Pathology
- Publication Details
- Applied and environmental microbiology, Vol.72(11), pp.6938-6947
- Academic Unit
- Veterinary Clinical Sciences, Department of; Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- American Society for Microbiology
- Identifiers
- 99900547814501842
- Language
- English
- Resource Type
- Journal article