Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

S Ziemin-van der Poel; N R McCabe; H J Gill; R Espinosa; Y Patel; A Harden; P Rubinelli; S D Smith; M M LeBeau; J D Rowley

doi:10.1073/pnas.88.23.10735

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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

S Ziemin-van der Poel, N R McCabe, H J Gill, R Espinosa, Y Patel, A Harden, P Rubinelli, S D Smith, M M LeBeau and J D Rowley

Proceedings of the National Academy of Sciences - PNAS, Vol.88(23), pp.10735-10739

12/01/1991

DOI: https://doi.org/10.1073/pnas.88.23.10735

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https://hdl.handle.net/2376/107839

PMCID: PMC53005

PMID: 1720549

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Abstract

Recurring chromosomal translocations involving chromosome 11, band q23, have been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We recently showed that breakpoints in four 11q23 translocations, t(4;11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci. We have identified within the CD3 yeast artificial chromosome a transcription unit that spans the breakpoint junctions of the 4;11, 9;11, and 11;19 translocations, and we describe two other, related transcripts that are upregulated in the RS4;11 cell line. We have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia.

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Title: Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
Creators: S Ziemin-van der Poel - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
N R McCabe - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
H J Gill - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
R Espinosa - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
Y Patel - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
A Harden - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
P Rubinelli - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
S D Smith - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
M M LeBeau - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
J D Rowley - Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.88(23), pp.10735-10739
Academic Unit: Molecular Biosciences, School of
Identifiers: 99900546986501842
Language: English
Resource Type: Journal article