Identification of a population of sleep-active cerebral cortex neurons

Dmitry Gerashchenko; Jonathan P Wisor; Deirdre Burns; Rebecca K Reh; Priyattam J Shiromani; Takeshi Sakurai; Horacio O de la Iglesia; Thomas S Kilduff

doi:10.1073/pnas.0803125105

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Identification of a population of sleep-active cerebral cortex neurons

Journal article

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Identification of a population of sleep-active cerebral cortex neurons

Dmitry Gerashchenko, Jonathan P Wisor, Deirdre Burns, Rebecca K Reh, Priyattam J Shiromani, Takeshi Sakurai, Horacio O de la Iglesia and Thomas S Kilduff

Proceedings of the National Academy of Sciences - PNAS, Vol.105(29), pp.10227-10232

07/22/2008

DOI: https://doi.org/10.1073/pnas.0803125105

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https://hdl.handle.net/2376/101724

PMCID: PMC2481371

PMID: 18645184

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Abstract

Biological Sciences

neuronal NOS

interneuron

sleep deprivation

Fos

wakefulness

The presence of large-amplitude, slow waves in the EEG is a primary characteristic that distinguishes cerebral activity during sleep from that which occurs during wakefulness. Although sleep-active neurons have been identified in other brain areas, neurons that are specifically activated during slow-wave sleep have not previously been described in the cerebral cortex. We have identified a population of cells in the cortex that is activated during sleep in three mammalian species. These cortical neurons are a subset of GABAergic interneurons that express neuronal NOS (nNOS). Because Fos expression in these sleep-active, nNOS-immunoreactive (nNOS-ir) neurons parallels changes in the intensity of slow-wave activity in the EEG, and these neurons are innvervated by neurotransmitter systems previously implicated in sleep/wake control, cortical nNOS-ir neurons may be part of the neurobiological substrate that underlies homeostatic sleep regulation.

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Title: Identification of a population of sleep-active cerebral cortex neurons
Creators: Dmitry Gerashchenko - Biosciences Division, SRI International, Menlo Park, CA 94025
Jonathan P Wisor - Biosciences Division, SRI International, Menlo Park, CA 94025
Deirdre Burns - Biosciences Division, SRI International, Menlo Park, CA 94025
Rebecca K Reh - Department of Biology, University of Washington, Seattle, WA 98195-1800
Priyattam J Shiromani - Department of Neurology, West Roxbury VA Medical Center and Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132; and
Takeshi Sakurai - Department of Molecular Neuroscience and Integrative Physiology, Kanazawa University, Kanazawa 920-8640, Japan
Horacio O de la Iglesia - Department of Biology, University of Washington, Seattle, WA 98195-1800
Thomas S Kilduff - Biosciences Division, SRI International, Menlo Park, CA 94025
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.105(29), pp.10227-10232
Academic Unit: Biomedical Sciences, Department of
Publisher: National Academy of Sciences
Identifiers: 99900546516901842
Language: English
Resource Type: Journal article