Journal article
Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution
Immunology, Vol.92(3), pp.340-345
11/1997
Handle:
https://hdl.handle.net/2376/114368
PMCID: PMC1363794
PMID: 9486106
Abstract
We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215,000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2, CD4, and CD8. The second population expresses CD2 and CD8 but not WC1 and appears to have a T-cell receptor (TCR) rearrangement distinct from that of the WC1+ population. The WC1- population is found in large numbers in spleen and intestine. In addition, this subset is not recognized by a number of monoclonal antibodies (mAbs) specific for TCR families that are well represented in the WC1+ population. The results indicate that the gamma delta T-cell population in cattle is considerably larger than previously described and that this population can be subdivided into two distinct subsets based on cell-surface phenotype and tissue distribution.
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Details
- Title
- Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution
- Creators
- N D Machugh - International Livestock Research Institute Nairobi, KenyaJ K Mburu - International Livestock Research Institute Nairobi, KenyaM J Carol - International Livestock Research Institute Nairobi, KenyaC R Wyatt - International Livestock Research Institute Nairobi, KenyaJ A Orden - International Livestock Research Institute Nairobi, KenyaW C Davis - International Livestock Research Institute Nairobi, Kenya
- Publication Details
- Immunology, Vol.92(3), pp.340-345
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Identifiers
- 99900548292601842
- Language
- English
- Resource Type
- Journal article