Identifying coevolving loci using interspecific genetic correlations

Scott L Nuismer; Christina E Jenkins; Mark F Dybdahl

doi:10.1002/ece3.3107

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Identifying coevolving loci using interspecific genetic correlations

Journal article

Open access

Peer reviewed

Identifying coevolving loci using interspecific genetic correlations

Scott L Nuismer, Christina E Jenkins and Mark F Dybdahl

Ecology and evolution, Vol.7(17), pp.6894-6903

09/2017

DOI: https://doi.org/10.1002/ece3.3107

Handle:

https://hdl.handle.net/2376/106781

PMCID: PMC5587482

PMID: 28904769

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Abstract

local adaptation

virulence

Original Research

infection genetics

coevolution

association study

landscape genetics

genetics of adaptation

resistance

SNP genotyping

genome scans

Evaluating the importance of coevolution for a wide range of evolutionary questions, such as the role parasites play in the evolution of sexual reproduction, requires that we understand the genetic basis of coevolutionary interactions. Despite its importance, little progress has been made identifying the genetic basis of coevolution, largely because we lack tools designed specifically for this purpose. Instead, coevolutionary studies are often forced to re‐purpose single species techniques. Here, we propose a novel approach for identifying the genes mediating locally adapted coevolutionary interactions that relies on spatial correlations between genetic marker frequencies in the interacting species. Using individual‐based multi‐locus simulations, we quantify the performance of our approach across a range of coevolutionary genetic models. Our results show that when one species is strongly locally adapted to the other and a sufficient number of populations can be sampled, our approach accurately identifies functionally coupled host and parasite genes. Although not a panacea, the approach we outline here could help to focus the search for coevolving genes in a wide variety of well‐studied systems for which substantial local adaptation has been demonstrated.

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Title: Identifying coevolving loci using interspecific genetic correlations
Creators: Scott L Nuismer - University of Idaho
Christina E Jenkins - Washington State University
Mark F Dybdahl - Washington State University
Publication Details: Ecology and evolution, Vol.7(17), pp.6894-6903
Academic Unit: Biological Sciences, School of
Publisher: John Wiley and Sons Inc; Hoboken
Grant note: DEB 1118947; DEB 1450653 / National Science Foundation
Identifiers: 99900546970001842
Language: English
Resource Type: Journal article