Journal article
Immune function in Amazonian horticulturalists
Annals of human biology, Vol.43(4), pp.382-396
07/2016
Handle:
https://hdl.handle.net/2376/104892
PMCID: PMC4976077
PMID: 27174705
Abstract
Amazonian populations are exposed to diverse parasites and pathogens, including protozoal, bacterial, fungal and helminthic infections. Yet much knowledge of the immune system is based on industrialised populations where these infections are relatively rare.
This study examines distributions and age-related differences in 22 measures of immune function for Bolivian forager-horticulturalists and US and European populations.
Subjects were 6338 Tsimane aged 0-90 years. Blood samples collected between 2004-2014 were analysed for 5-part blood differentials, C-reactive protein, erythrocyte sedimentation rate (ESR) and total immunoglobulins E, G, A and M. Flow cytometry was used to quantify naïve and non-naïve CD4 and CD8 T cells, natural killer cells, and B cells.
Compared to reference populations, Tsimane have elevated levels of most immunological parameters, particularly immunoglobulins, eosinophils, ESR, B cells, and natural killer cells. However, monocytes and basophils are reduced and naïve CD4 cells depleted in older age groups.
Tsimane ecology leads to lymphocyte repertoires and immunoglobulin profiles that differ from those observed in industrialised populations. These differences have consequences for disease susceptibility and co-vary with patterns of other life history traits, such as growth and reproduction.
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Details
- Title
- Immune function in Amazonian horticulturalists
- Creators
- Aaron D Blackwell - b Tsimane Health and Life History Project , San Borja , BoliviaBenjamin C Trumble - d School of Human Evolution and Social Change, Arizona State University , Tempe , AZ , USAIvan Maldonado Suarez - b Tsimane Health and Life History Project , San Borja , BoliviaJonathan Stieglitz - f Institute for Advanced Study in Toulouse , Toulouse , FranceBret Beheim - e Department of Anthropology , University of New Mexico , Albuquerque , NM , USAJ Josh Snodgrass - g Department of Anthropology , University of Oregon , Eugene , OR , USAHillard Kaplan - e Department of Anthropology , University of New Mexico , Albuquerque , NM , USAMichael Gurven - b Tsimane Health and Life History Project , San Borja , Bolivia
- Publication Details
- Annals of human biology, Vol.43(4), pp.382-396
- Academic Unit
- Anthropology, Department of
- Publisher
- England
- Grant note
- R56 AG024119 / NIA NIH HHS P01 AG022500 / NIA NIH HHS R01 AG024119 / NIA NIH HHS
- Identifiers
- 99900546628601842
- Language
- English
- Resource Type
- Journal article