Journal article
Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting
Ticks and tick-borne diseases, Vol.3(3), pp.170-178
06/2012
Handle:
https://hdl.handle.net/2376/116093
PMID: 22658857
Abstract
Commercial vaccines based on the tick gut protein Bm86 have been successful in controlling the one-host tick Rhipicephalus (Boophilus) microplus and provide heterologous protection against certain other non-target ixodid tick species. This cross protection, however, does not extend to the three-host tick R. appendiculatus, the vector of the protozoan parasite Theileria parva. When transmitted to cattle, T. parva causes the often fatal disease East Coast fever. Here, we used insect cell-expressed recombinant versions of the R. appendiculatus homologs of Bm86, named Ra86, to vaccinate cattle. We measured multiple fitness characteristics for ticks that were fed on cattle Ra86-vaccinated or unvaccinated. The Ra86 vaccination of cattle significantly decreased the molting success of nymphal ticks to the adult stage. Modeling simulations based on our empirical data suggest that repeated vaccinations using Ra86 could reduce tick populations over successive generations. Vaccination with Ra86 could thus form a component of integrated control strategies for R. appendiculatus leading to a reduction in use of environmentally damaging acaricides.
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Details
- Title
- Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting
- Creators
- Cassandra Olds - International Livestock Research Institute, Box 30709, Nairobi 00100, KenyaStephen MwauraDavid CrowderDavid OdongoMonique van OersJeb OwenRichard BishopClaudia Daubenberger
- Publication Details
- Ticks and tick-borne diseases, Vol.3(3), pp.170-178
- Academic Unit
- Paul G. Allen School for Global Animal Health; Entomology, Department of
- Publisher
- Netherlands
- Identifiers
- 99900548068701842
- Language
- English
- Resource Type
- Journal article