Journal article
Immunization of cattle with recombinant Babesia bovis merozoite surface antigen-1
Infection and immunity, Vol.63(1), pp.349-352
01/1995
Handle:
https://hdl.handle.net/2376/114748
PMCID: PMC172999
PMID: 7806376
Abstract
Cattle immunized with a recombinant merozoite surface antigen-1 molecule (MSA-1) produced high-titered antibody that reacted with the surface of the parasite and neutralized merozoite infectivity in vitro. However, recombinant MSA-1 immunization did not confer protection against challenge with virulent Babesia bovis. These results indicate that antibody-mediated neutralization of merozoite infectivity in vitro, at least for MSA-1-specific antibody, does not reflect in vivo protective immunity to babesiosis.
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Details
- Title
- Immunization of cattle with recombinant Babesia bovis merozoite surface antigen-1
- Creators
- S A Hines - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040G H Palmer - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040D P Jasmer - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040W L Goff - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040T F McElwain - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040
- Publication Details
- Infection and immunity, Vol.63(1), pp.349-352
- Academic Unit
- Veterinary Medicine, College of; Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Identifiers
- 99900547318601842
- Language
- English
- Resource Type
- Journal article